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MetabolomicsSodium Butyrate mediates Histone Crotonylation and Alleviated Neonatal Rats Hypoxic-Ischemic Brain Injury Through Gut-Brain Axis (untargeted fecal metabolomics)

Neonatal hypoxic-ischemic encephalopathy (HIE) refers to nervous system damage caused by perinatal hypoxia, which is the major cause of long-term neuro-developmental disorders in surviving infants. However, the mechanisms still require further investigation. In this study, we found that the butan...

2022-10-12 | MTBLS4932 | MetaboLights
GenomicsIdentification of 67 histone marks and histone lysine crotonylation as a new type of histone modification
We report the identification of 67 previously undescribed histone modifications, increasing the current number of known histone marks by about 70%. We further investigated one of the marks, lysine crotonylation (Kcr), confirming that it represents an evolutionarily-conserved histone posttranslationa...
ORGANISM(S): Mus musculus 
2011-10-06 | E-GEOD-32663 | biostudies-arrayexpress
MetabolomicsSodium Butyrate mediates Histone Crotonylation and Alleviated Neonatal Rats Hypoxic-Ischemic Brain Injury Through Gut-Brain Axis (targeted SCFA brain metabolomics)

Neonatal hypoxic-ischemic encephalopathy (HIE) refers to nervous system damage caused by perinatal hypoxia, which is the major cause of long-term neuro-developmental disorders in surviving infants. However, the mechanisms still require further investigation. In this study, we found that the butan...

2022-10-12 | MTBLS4933 | MetaboLights
ProteomicsFirst comprehensive proteome analysis of lysine crotonylation in Streptococcus agalactiae, a pathogen causing meningoencephalitis in teleosts
In Homo sapiens, Streptococcus agalactiae is a common colonizer of the rectovaginal tract and a fundamental cause of neonatal and non-pregnant adults infectious diseases. It also causes infectious disease in fish which compromises food safety as well as possesses a zoonotic risk. Lysine crotonylatio...
ORGANISM(S): Enterococcus faecalis (Streptococcus faecalis) 
2021-12-30 | PXD026445 | Pride
Streptococcus agalactiae  crotonylation  virulence factors  proteomics 
ProteomicsGlobal Proteomic Analysis of Lysine crotonylation in The Plant Pathogen Botrytis cinerea
Lysine crotonylation (Kcr), a recently discovered post-translational modification, plays a key role in the regulation of diverse cellular processes. Botrytis cinerea is a destructive necrotrophic fungal pathogen distributed worldwide with broad ranging hosts. However, the functions of Kcr are unknow...
ORGANISM(S): Caenorhabditis elegans 
2020-09-07 | PXD019358 | Pride
Lc-ms/ms Botrytis cinerea Lysine crotonylation 
ProteomicsSystematic Analysis of the Lysine Crotonylome and multiple PTM analysis (acetylation, succinylation and crotonylation) in Candida albicans
LC-MS/MS was used to carry out the analysis of the crotonylome in C. albicans (Candida albicans) comprehensively in our study. Generally, 5242 specific crotonylated sites of 1584 crotonylated proteins were detected among 9038 proteins in C. albicans. The crotonylome involved in the regulation of met...
ORGANISM(S): Candida albicans (Yeast) 
2021-01-08 | PXD018848 | Pride
C. albicans  crotonylome  histone  lysine crotonylation motif  ppi 
ProteomicsHistone lysine acetylation, butyrylation, and crotonylation dynamics and functional interplay in rice under starvation and submergence
Histone lysine acylations are regulated by primary metabolism in animal cells. However, histone non-acetyl acylation is not yet studied in plants that have distinct primary metabolic pathways. In this work, we detected rice histone lysine butyrylation (Kbu) and crotonylation (Kcr) sites by mass spec...
ORGANISM(S): Oryza sativa (Rice) 
2018-09-06 | PXD009091 | Pride
Crotonylation Butyrylation Histone Rice 
ProteomicsQualitative Proteome-wide Analysis Reveal the Diverse Functions of Lysine Crotonylation in Dendrobium huoshanense C. Z. Tang et S. J. Cheng
Lysine crotonylation of histone proteins is a newly identified post-translational modification with diversified cellular functions. However, there’s few reports on lysine crotonylation of non-histone proteins in fruit plant cells. By using high-resolution LC-MS coupled with highly sensitive specific...
ORGANISM(S): Dendrobium huoshanense 
2021-11-29 | PXD028293 | Pride
Dendrobium huoshanense  lysine crotonylation  polysaccharide biosythesis 
ProteomicsLarge-scale identification of lysine crotonylation
Lysine crotonylation on histones is a recently identified post-translational modification that has been demonstrated to associate with active promoters and to directly stimulate transcription.Given that crotonyl-CoA is essential for the acyl transfer reaction and it is a metabolic intermediate widel...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2016-06-11 | MSV000079810 | MassIVE
ProteomicsGlobal Proteomic Analysis of Lysine Crotonylation in H. axyridis
Lysine crotonylation (Kcr), a recently discovered post-translational modification, plays a key role in the regulation of diverse cellular processes.. However, the functions of Kcr are unknown in H. axyridis .
ORGANISM(S): Harmonia axyridis 
2021-09-28 | PXD024421 | Pride
Lysine crotonylation Ptm H. axyridis 
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