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MetabolomicsPKM2 methylation by CARM1 activates aerobic glycolysis to promote tumorigenesis
Metabolic reprogramming is a hallmark of cancer. Herein we discover that the key glycolytic enzyme pyruvate kinase M2 isoform (PKM2), but not the related isoform PKM1, is methylated by co-activator-associated arginine methyltransferase 1 (CARM1). PKM2 methylation reversibly shifts the balance of met...
2021-07-30 | MTBLS533 | MetaboLights
ProteomicsTwo DOT1 enzymes cooperatively mediate efficient ubiquitin-independent histone H3 lysine 76 tri-methylation in kinetoplastids
In higher eukaryotes, a single DOT1 histone H3 lysine 79 (H3K79) methyltransferase processively produces H3K79me2/me3 from me0 through histone H2B mono-ubiquitin interaction. The early-branched kinetoplastid Trypanosoma brucei harbors the essential H3K76 di-methyltransferase DOT1A and the non-essent...
ORGANISM(S): Trypanosoma Brucei (ncbitaxon:5691) 
2022-11-09 | MSV000090680 | MassIVE
ProteomicsLysine Methylation Promotes VEGFR-2 Activation and Angiogenesis
We have used a chimeric VEGFR-2 in which the extracellular domain of mouse VEGFR-2 was replaced with the extracellular domain of human CSF-1 receptor. VEGFR-2 was immunoprecipitated with anti-VEGFR-2 antibody from PAE cells ectopically expressing VEGFR-2. The immunoprecipitated proteins were eluted...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2019-11-22 | PXD000520 | Pride
In-gel digestion Lc-ms/ms 
GenomicsCpG islands recruit a histone H3 lysine 36 demethylase [Illumina sequencing data]
Eukaryotic gene expression profiles are largely defined by transcription factors that recognize specific DNA sequences in gene regulatory regions and impact RNA polymerase recruitment and transcription. In addition to specific core promoter regulatory elements, up to 70% of genes in higher eukaryote...
ORGANISM(S): Mus musculus 
2010-04-27 | E-GEOD-18588 | biostudies-arrayexpress
ProteomicsDetection of CHMP2B methylation
Characterization of CHMP2B methylation by the lysine methyl transferase SMYD2 : identification of the lysine methylated by SMYD2
ORGANISM(S): Homo sapiens (Human) 
2024-03-18 | PXD041760 | Pride
Lysine methylation 
ProteomicsQuantitative profiling of the enzymatic activity of the protein lysine mono-methyltransferase SMYD2 using SILAC-based proteomics
The significance of non-histone lysine methylation in cell biology and human disease is an emerging area of research exploration, and small molecule inhibitors that selectively and potently target “writers” and “erasers” of methyl-lysine, such as the protein lysine mono-methyltransferase SMYD2, are ...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-29 | MSV000080785 | MassIVE
TranscriptomicsThe SET-domain protein SUVR5 mediates H3K9me2 deposition and silencing at stimulus response genes in a DNA methylation independent manner [ChIP-chip]
In eukaryotic cells, environmental and developmental signals alter chromatin structure and modulate gene expression. Heterochromatin constitutes the transcriptionally inactive state of the genome and in plants and mammals is generally characterized by DNA methylation and histone modifications such a...
ORGANISM(S): Arabidopsis thaliana 
2014-06-06 | E-GEOD-58030 | biostudies-arrayexpress
GenomicsCpG islands recruit a histone H3 lysine 36 demethylase
This SuperSeries is composed of the following subset Series: GSE18588: CpG islands recruit a histone H3 lysine 36 demethylase [Illumina sequencing data] GSE21201: CpG islands recruit a histone H3 lysine 36 demethylase [Agilent data] Refer to individual Series
ORGANISM(S): Homo sapiens 
2010-04-26 | E-GEOD-21202 | biostudies-arrayexpress
GenomicsHistone H3 lysine 9 di-methylation as an epigenetic signature of the interferon response (sequencing)
Effective anti-viral immunity depends on the ability of infected cells or cells triggered with virus-derived nucleic acids to produce type I interferon (IFN), which activates transcription of numerous antiviral genes. However, disproportionately strong or chronic IFN expression is a common cause of ...
ORGANISM(S): Mus musculus 
2012-03-02 | E-GEOD-22102 | biostudies-arrayexpress
GenomicsExpanding the CTD code: methylation of non-consensus Lysine residues marks early transcription in mammalian cells
Dynamic post-translational modification of RNA polymerase II (RNAPII) coordinates the co-transcriptional recruitment of enzymatic complexes that regulate chromatin states and co-transcriptional processing of nascent RNA. Extensive phosphorylation of serine residues occurs at the structurally-disorde...
ORGANISM(S): Mus musculus 
2015-12-22 | E-GEOD-72876 | biostudies-arrayexpress
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