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ProteomicsThe dual life of disordered lysine-rich domains of snoRNPs in rRNA modification and nucleolar compaction
Intrinsically disordered regions (IDRs) are highly enriched in the nucleolar proteome but their physiological role in ribosome assembly remains poorly understood. Our study reveals the functional plasticity of the extremely abundant lysine-rich IDRs of small nucleolar ribonucleoprotein particles (sn...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2024-10-18 | PXD056946 | Pride
Snornp Lysine-rich idr Saccharomyces cerevisiae 
UnknownThe dual life of disordered lysine-rich domains of snoRNPs in rRNA modification and nucleolar compaction.
Not available
S-EPMC11528048 | biostudies-literature
GenomicsG9a/GLP-dependent H3K9me2 patterning alters chromatin structure at CpG islands in hematopoietic progenitors.
We profiled chromatin accessibility across the genome of HSPCs treated with either a small molecule inhibitor of G9a/GLP or DMSO. We observed that chromatin accessibility is dramatically altered at the regions of H3K9me2 nucleation. We have characterized the regions of H3K9me2 nucleation, revealing ...
ORGANISM(S): Homo sapiens 
2014-09-25 | E-GEOD-59749 | biostudies-arrayexpress
UnknownStructural dynamics of IDR interactions in human SFPQ and implications for liquid-liquid phase separation.
Not available
S-EPMC12216677 | biostudies-literature
GenomicsThe dual life of nucleolar intrinsically disordered lysine-rich domains: from rRNA modification to nucleolar compaction
Co-transcriptional rRNA modification RiboMethSeq
PRJEB67499 | ENA
GenomicsThe dual life of nucleolar intrinsically disordered lysine-rich domains: from rRNA modification to nucleolar compaction
Co-transcriptional rRNA modification HydraPsiSeq
PRJEB67500 | ENA
UnknownMolecular Mechanisms of Functional Modulation of Transcriptional Coactivator PC4 via Phosphorylation on Its Intrinsically Disordered Region.
Not available
S-EPMC10134458 | biostudies-literature
UnknownAn Intrinsically Disordered Region of Histone Demethylase KDM5A Activates Catalysis Through Interactions With the Nucleosomal Acidic Patch and DNA.
Not available
S-EPMC12443421 | biostudies-literature
ProteomicsAn intrinsically disordered region of histone demethylase KDM5A regulates catalysis through interactions with the nucleosomal acidic patch and DNA
KDM5A lysine demethylase conformation was probed by BS3 crosslinking in the presence and absence of DNA. Crosslinked proteins were reduced, alkylated with iodoacetamide, trypsin digest, and labeled with TMT6plex reagent prior to mixing and acquisition on an Orbitrap Exploris equiped with a FAIMS sou...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2025-02-10 | MSV000097094 | MassIVE
ProteomicsStructural basis of the SWI/SNF-bound transcription pre-initiation complex
DSSO crosslinking of SwiSnf + Mediator + Pre-initiation Complex. Two replicate experiments starting with 300 ug of protein and 6 mM DSSO. Crosslinked peptides were fractionated by size-exclusion chromatography (SEC) and 8 SEC were analyzed by LC-MS on an Orbitrap Exploris 480 instrument. The first s...
ORGANISM(S): Saccharomyces Cerevisiae (ncbitaxon:4932) 
2025-05-14 | MSV000097892 | MassIVE
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