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ProteomicsAtg8ylation coordinates stress granule formation and mTOR inactivation in response to lysosomal damage
Stress granule formation is a part of cellular homeostatic responses, with prototypical inducers being viral infections, heat shock and oxidative damage. Here we show that lysosomal damage is a previously unappreciated robust inducer of stress granule formation interlinked with mTOR inactivation dur...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
MSV000088152 | MassIVE
ProteomicsMembrane atg8ylation coordinates stress granule formation and mTOR inactivation in response to lysosomal damage
We report that lysosomal damage is a hitherto unknown inducer of stress granule (SG) formation and that the process termed membrane atg8ylation coordinates SG formation with mTOR inactivation during lysosomal stress. SGs were induced by lysosome-damaging agents including SARS-CoV-2ORF3a, Mycobacteri...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2022-06-09 | MSV000089622 | MassIVE
GenomicsMitochondrial Protein Import Stress Causes Lysosomal Damage and Tissue Atrophy
Mitochondrial Protein Import Stress Causes Lysosomal Damage and Tissue Atrophy
PRJNA1188003 | ENA
ProteomicsProteins enriched on damaged lysosomes in 293T
Lysosomal membrane permeabilization (LMP) or lysosomal membrane damage is commonly associated with aging and age-related diseases. In searching for cellular mechanisms in response to LMP, we used a proteomic approach to identify proteins enriched on damaged lysosomes. This unbiased approach identifi...
ORGANISM(S): Homo sapiens (Human) 
2022-09-07 | PXD028852 | Pride
Human Lysosomal membrane permeabilization 
ProteomicsProteome changes of RPE-1 cells in response to lysosomal damage
The lysosomal damage response plays a critical role in the maintenance of cellular homeostasis. While the repair and autophagic elimination mechanisms of damaged lysosomes have been elucidated, the early signal transduction and subsequent gene expression in response to lysosomal damage remain elusiv...
ORGANISM(S): Homo sapiens (Human) 
2025-08-30 | PXD058072 | Pride
Dia Human cell Lc-ms Lysosomal damage 
GenomicsThe antibacterial factor APOL3 couples lysosomal damage to mitochondrial DNA efflux and type I IFN induction
The antibacterial factor APOL3 couples lysosomal damage to mitochondrial DNA efflux and type I IFN induction
PRJNA1375674 | ENA
ProteomicsMitochondrial Protein Import Stress Causes Lysosomal Damage and Tissue Atrophy
Mitochondrial abnormalities are commonly associated with aging-related degenerative disease and the atrophy of tissues including muscle and brain. Whether bioenergetic defect is the sole pathogenic factor has been long questioned. Lysosomal damage is another hallmark of degenerative disease. However...
ORGANISM(S): Mus musculus (Mouse) 
2026-03-27 | PXD058344 | Pride
Mpos Mouse Muscle atrophy Mitochondria 
ProteomicsProteome changes of RPE-1 cells in response to lysosomal damage with the TAK1 inhibitor
The lysosomal damage response plays a critical role in the maintenance of cellular homeostasis. While the repair and autophagic elimination mechanisms of damaged lysosomes have been elucidated, the early signal transduction and subsequent gene expression in response to lysosomal damage remain elusiv...
ORGANISM(S): Homo sapiens (Human) 
2025-08-30 | PXD058075 | Pride
Dia Human cell Lc-ms Lysosomal damage 
ProteomicsPhosphoproteome changes of RPE-1 cells in response to lysosomal damage with the TAK1 inhibitor
The lysosomal damage response plays a critical role in the maintenance of cellular homeostasis. While the repair and autophagic elimination mechanisms of damaged lysosomes have been elucidated, the early signal transduction and subsequent gene expression in response to lysosomal damage remain elusiv...
ORGANISM(S): Homo sapiens (Human) 
2025-08-30 | PXD058080 | Pride
Phosphoproteome Human cell Lc-ms Lysosomal damage Dda 
ProteomicsA Lysosome membrane regeneration pathway depends on TBC1D15 and autophagic lysosomal reformation proteins
Acute lysosomal membrane damage reduces the cellular population of functional lysosomes. However, these damaged lysosomes have a remarkable recovery potential independent of lysosomal biogenesis and remain unaffected in TFEB/TFE3-depleted cells. We combined proximity labelling based proteomics, bioc...
ORGANISM(S): Homo sapiens (Human) 
2023-03-07 | PXD040191 | Pride
Autophagy Lysosomal regeneration Lysosomes Autophagic lysosomal reformation Tbc family of proteins 
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