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UnknownSpatiotemporal proteomics reveals the biosynthetic lysosomal membrane protein interactome in neurons.
Not available
S-EPMC11868546 | biostudies-literature
ProteomicsMUC13-associated molecular interactome in pancreatic cancer
MUC13 has emerged as a critical molecular player that is involved in tumorigenesis, cancer progression, metastasis and evade immune surveillance, including in pancreatic cancer. In this report, we have identified MUC13 molecular interactome using an integrated immunoprecipitation and liquid chromato...
ORGANISM(S): Homo Sapiens (human) 
2025-11-15 | PXD070763 | JPOST Repository
ProteomicsSpatiotemporal proteomics reveals the biosynthetic lysosomal membrane protein interactome in neurons
Spatiotemporal proteomics reveals the biosynthetic lysosomal membrane protein interactome in neurons. Lysosomes are membrane-bound organelles critical for maintaining cellular homeostasis. Delivery of biosynthetic lysosomal proteins to lysosomes is crucial to orchestrate proper lysosomal function. H...
ORGANISM(S): Rattus norvegicus (Rat) 
2025-02-27 | PXD056787 | Pride
Protein synchronization Potatomap Proximity labeling 
ProteomicsCross-linking of the Endolysosomal System Reveals Potential Flotillin Structures and Cargo
Lysosomes are well-established as the main cellular organelles for the degradation of macromolecules and emerging as regulatory centers of metabolism. They are of crucial importance for cellular homeostasis, which is exemplified by a plethora of disorders related to alterations in lysosomal function...
ORGANISM(S): Homo sapiens (Human) 
2022-10-22 | PXD030532 | Pride
Lysosomal interactome Cross-linking ms 
GenomicsATG conjugation system -dependent and -independent mechanisms underlie lysosomal stress-induced TFEB regulation
ATG conjugation system -dependent and -independent mechanisms underlie lysosomal stress-induced TFEB regulation
PRJNA985714 | ENA
UnknownLysosomal escape and TMEM106B fibrillar core determine TDP-43 seeding outcomes.
Not available
S-EPMC12767511 | biostudies-literature
ProteomicsLOSS OF THE BATTEN DISEASE PROTEIN CLN3 LEADS TO MIS-TRAFFICKING OF M6PR AND DEFECTIVE AUTOPHAGIC-LYSOSOMAL REFORMATION
Batten disease, one of the most devastating types of neurodegenerative lysosomal storage disorders, is caused by mutations in CLN3. Here, we show that CLN3 is a vesicular trafficking hub connecting the Golgi and lysosome compartments. Proteomic analysis reveals that CLN3 interacts with several endo-...
ORGANISM(S): Homo sapiens (Human) 
2023-06-20 | PXD031582 | Pride
Human Cln3 Batten Lysosome 
TranscriptomicsATG conjugation system -dependent and -independent mechanisms underlie lysosomal stress-induced TFEB regulation
Transcription factor EB (TFEB), well characterized as a master regulator of autophagy and lysosomal biogenesis, is translocated to the nucleus and activated by varieties of cellular stresses including starvation and lysosomal damage. However, compared to the starvation condition, the molecular mecha...
ORGANISM(S): Homo sapiens 
2025-01-31 | GSE235340 | GEO
UnknownKir2.1 Interactome Mapping Uncovers PKP4 as a Modulator of the Kir2.1-Regulated Inward Rectifier Potassium Currents.
Not available
S-EPMC8143648 | biostudies-literature
UnknownAMPK, a Regulator of Metabolism and Autophagy, Is Activated by Lysosomal Damage via a Novel Galectin-Directed Ubiquitin Signal Transduction System.
Not available
S-EPMC7785494 | biostudies-literature
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