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GenomicsOxidative stress induces lysosomal membrane permeabilization and ceramide accumulation in retinal pigment epithelial cells
Oxidative stress induces lysosomal membrane permeabilization and ceramide accumulation in retinal pigment epithelial cells
PRJNA994552 | ENA
GenomicsEndocytosed dsRNAs induce lysosomal membrane permeabilization that allows cytosolic dsRNA translocation for Drosophila RNAi response
Endocytosed dsRNAs induce lysosomal membrane permeabilization that allows cytosolic dsRNA translocation for Drosophila RNAi response
PRJNA1023479 | ENA
ProteomicsProteins enriched on damaged lysosomes in 293T
Lysosomal membrane permeabilization (LMP) or lysosomal membrane damage is commonly associated with aging and age-related diseases. In searching for cellular mechanisms in response to LMP, we used a proteomic approach to identify proteins enriched on damaged lysosomes. This unbiased approach identifi...
ORGANISM(S): Homo sapiens (Human) 
2022-09-07 | PXD028852 | Pride
Human Lysosomal membrane permeabilization 
TranscriptomicsOxidative stress induces lysosomal membrane permeabilization and ceramide accumulation in retinal pigment epithelial cells
Oxidative stress has been implicated in the pathogenesis of age-related macular degeneration, the leading cause of blindness in older adults, with retinal pigment epithelium (RPE) cells playing a key role. To better understand the cytotoxic mechanisms underlying oxidative stress, we used a mouse mod...
ORGANISM(S): Mus musculus 
2023-07-13 | GSE237309 | GEO
UnknownContribution of Particle-Induced Lysosomal Membrane Hyperpolarization to Lysosomal Membrane Permeabilization.
Not available
S-EPMC7956429 | biostudies-literature
GenomicsEndocytosed dsRNAs induce lysosomal membrane permeabilization that allows cytosolic dsRNA translocation for Drosophila RNAi response
RNA interference (RNAi) is a gene-silencing mechanism triggered by the cytosolic entry of double-stranded RNAs (dsRNAs). Many animal cells internalize extracellular dsRNAs via endocytosis for RNAi induction. However, it is not clear how the endocytosed dsRNAs are translocated into the cytosol across...
ORGANISM(S): Drosophila melanogaster 
2024-07-07 | GSE244523 | GEO
UnknownMLKL polymerization-induced lysosomal membrane permeabilization promotes necroptosis.
Not available
S-EPMC10782024 | biostudies-literature
ProteomicsOxidative stress induces lysosomal membrane permeabilization and ceramide accumulation in retinal pigment epithelial cells
Oxidative stress has been implicated in the pathogenesis of age-related macular degeneration(AMD), the leading cause of blindness in the elderly, with retinal pigment epithelial (RPE) cells playing a key role. To better understand the cytotoxic mechanisms underlying oxidative stress, we used cell cu...
ORGANISM(S): Mus musculus (Mouse) 
2023-07-19 | PXD043613 | Pride
Oxidative stress Lysosome Age-related macular degeneration Aging Retina 
UnknownHeat shock protein 70 promotes cell survival by inhibiting lysosomal membrane permeabilization.
Not available
S-EPMC2211935 | biostudies-literature
UnknownLysosomal lipid peroxidation contributes to ferroptosis induction via lysosomal membrane permeabilization.
Not available
S-EPMC11997074 | biostudies-literature
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