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ProteomicsProteomics of EBV-infected lytic and refractory cells
Most humans are infected with Epstein-Barr virus (EBV), a cancer-causing virus. While EBV generally persists silently in B lymphocytes, periodic lytic (re-)activation of latent virus is central to its life cycle and to most EBV-related diseases. However, a substantial fraction of EBV-infected B cell...
ORGANISM(S): Homo sapiens (Human) 
2016-04-27 | PXD001838 | Pride
Proteomic analysis Epstein-barr virus Lytic activation 
Proteomics,MultiomicsProteomics of EBV-infected lytic and refractory cells
Most humans are infected with Epstein-Barr virus (EBV), a cancer-causing virus. While EBV generally persists silently in B lymphocytes, periodic lytic (re-)activation of latent virus is central to its life cycle and to most EBV-related diseases. However, a substantial fraction of EBV-infected B cell...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2016-07-22 | MSV000079993 | MassIVE
ProteomicsMass spectrometry of human A549 cells transfected with EBV BRLF1
The immediate-early protein BRLF1 plays important roles in lytic infection of Epstein-Barr virus (EBV), in which it activates lytic viral transcription and replication. However, knowledge of the influence of BRLF1 on cellular gene expression and transcriptional reprogramming during the early lytic c...
ORGANISM(S): Homo Sapiens 
2020-10-13 | PXD021958 |
TranscriptomicsATAC-seq experiment in two versions of Raji cells with inducible BZLF1 variants prior to and after induction of EBV's lytic cycle by doxycycline.
The aim of the experiment was to identify accessible (open) chromatin regions in the genome prior to and post induction of EBV's lytic phase by the BZLF1 protein. Two versions of BZLF1 were employed: full-length and activation-domain (AD)-truncated BZLF1 non-induced and induced for 15 h. The experim...
ORGANISM(S): Homo sapiens 
2019-04-01 | E-MTAB-7789 | biostudies-arrayexpress
TranscriptomicsSignal Transducer and Activator of Transcription 3 limits Epstein-Barr virus lytic-activation in B lymphocytes.
We used microarrays to identify genes differentially expressed in EBV-infected human B cells supporting lytic replication vs. those refractory to EBV lytic replication. We used serum from EBV-positive subject (compared to serum from EBV-negative subject) to FACS-separate lytic and refractory cells f...
ORGANISM(S): Homo sapiens 
2013-08-21 | E-GEOD-49568 | biostudies-arrayexpress
TranscriptomicsEffect of endoplasmic reticulum stress on gene expression in lymphoblastoid cell lines.
The ER stress inducing agent Thapsigargin (TG) and/or the cytoprotective agent Salubrinal were applied to lymphoblastoid cell lines. TG induced lytic replication as well as a distinct pattern of gene expression changes. This study was designed to identify host genes mediating lytic replication secon...
ORGANISM(S): Homo sapiens 
2011-08-22 | E-GEOD-31447 | biostudies-arrayexpress
GenomicsNascent transcriptomics reveal cellular pro-lytic factors upregulated upstream of the latency-to-lytic switch protein of Epstein-Barr virus
Nascent transcriptomics reveal cellular pro-lytic factors upregulated upstream of the latency-to-lytic switch protein of Epstein-Barr virus
PRJNA592709 | ENA
UnknownSignal transducer and activator of transcription 3 limits Epstein-Barr virus lytic activation in B lymphocytes.
Not available
S-EPMC3807321 | biostudies-literature
UnknownCellular STAT3 functions via PCBP2 to restrain Epstein-Barr Virus lytic activation in B lymphocytes.
Not available
S-EPMC4403452 | biostudies-literature
TranscriptomicsNascent transcriptomics reveal cellular pro-lytic factors upregulated upstream of the latency-to-lytic switch protein of Epstein-Barr virus
Lytic activation from latency is a key transition point in the life cycle of herpesviruses. Epstein-Barr virus (EBV) is a human herpesvirus that can cause lymphomas, epithelial cancers, and other diseases, most of which require the lytic cycle. While the lytic cycle of EBV can be triggered by chemic...
ORGANISM(S): Homo sapiens 
2020-01-13 | GSE141220 | GEO
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