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ProteomicsCharacterization of m-lipin using HDX-MS
This project consists of two experiments. The first is mapping the binding interface between the isolated m-lip domain of mouse lipin and liposomes. The second experiments is mapping the binding interface between full length mouse lipin and liposomes. Looking at the isolated m-lip domain, we found t...
ORGANISM(S): Mus musculus (Mouse) 
2021-06-29 | PXD022172 | Pride
M-lip domain Mass spectrometry M-lipin Hdx-ms 
ProteomicsAnalysis of human AKT PH domain using limited proteolysis (LiP) followed by LC-MS/MS
We identified that a lncRNA named Long Intergenic Noncoding RNA for Kinase Activation (LINK-A, also LINC01139) directly and specifically interacts with AKT and PIP3. The LINK-A-AKT and -PIP3 interactions facilitate AKT recruitment and consequent activation. we also identified the single nucleotides ...
ORGANISM(S): Homo sapiens (Human) 
2017-02-10 | PXD005636 | Pride
Human Pip3 Akt Ph domain Lip Lc-ms/ms 
UnknownThe middle lipin domain adopts a membrane-binding dimeric protein fold.
Not available
S-EPMC8342540 | biostudies-literature
UnknownMonoclonal antibodies targeting the HR2 domain and the region immediately upstream of the HR2 of the S protein neutralize in vitro infection of severe acute respiratory syndrome coronavirus.
Not available
S-EPMC1346840 | biostudies-literature
TranscriptomicsTranscription profiling of human cell lines from Hay Wells Syndrome-Derived TAp63alphaQ540L mutant rveals impaired transcriptional and cell growth regulatory activity
p63 mutations have been associated with several human hereditary disorders characterized by ectodermal dysplasia such as EEC syndrome, ADULT syndrome and AEC syndrome . The location and functional effects of the mutations that underlie these syndromes reveal a striking genotype-phenotype correlati...
ORGANISM(S): Homo sapiens 
2008-06-16 | E-GEOD-8646 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of wild type and C/EBPbeta deficient mice during a partial hepatectomy time series to identify transcriptional targets of C/EBPbeta
The aim of this experiment was to use microarray analysis to compare the response of wild type (WT) and C/EBPbeta deficient (KO) mice during a partial hepatectomy time course in hopes of identifying transcriptional targets of C/EBPbeta. In addition, the WT time course alone was examined to analyze m...
ORGANISM(S): Mus musculus 
2006-10-03 | E-CBIL-16 | biostudies-arrayexpress
UnknownPhosphatidylserine enrichment in the nuclear membrane regulates key enzymes of phosphatidylcholine synthesis.
Not available
S-EPMC11329639 | biostudies-literature
ProteomicsParadoxical non-catalytic kinase functions are driven by inhibitor-induced displacement of autoinhibitory domains
Protein kinases are crucial regulators of cellular processes, and their dysregulation is frequently associated with human disorders. ATP-competitive type I inhibitors are widely used to block aberrant kinase activity. However, their effect on non-catalytic kinase functions such as conformation and p...
ORGANISM(S): Homo sapiens (Human) 
2026-06-17 | PXD069830 | Pride
Lip-ms Proximity labeling Structural proteomics Ap-ms Bioid 
TranscriptomicsThe Notch/Hes1 pathway sustains NF-M-NM-:B activation through CYLD repression in T cell leukemia
The NF-M-NM-:B pathway is a critical regulator of the immune system and has been implicated in cellular transformation and tumorigenesis. NF-M-NM-:B response is regulated by the activation state of the IM-NM-:B kinase (IKK) complex and triggered by a wide spectrum of stimuli. We previously reported ...
ORGANISM(S): Homo sapiens 
2011-05-07 | E-GEOD-20667 | biostudies-arrayexpress
ProteomicsPhosphatidate phosphatase Pah1 contains a novel RP domain that regulates its phosphorylation and function in yeast lipid synthesis
The Saccharomyces cerevisiae PAH1-encoded phosphatidate (PA) phosphatase, which catalyzes the Mg2+-dependent dephosphorylation of PA to produce diacylglycerol, is one of the most highly regulated enzymes in lipid metabolism. The enzyme controls whether cells utilize PA to produce membrane phospholi...
ORGANISM(S): Saccharomyces Cerevisiae (ncbitaxon:4932) 
2023-06-01 | MSV000092078 | MassIVE
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