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MetabolomicsSerine synthesis pathway enzyme PHGDH is critical for muscle cell biomass, anabolic metabolism and mTORC1 signaling

Cells use glycolytic intermediates for anabolism e.g., via the serine synthesis and pentose phosphate pathways. However, we still understand poorly how these metabolic pathways contribute to skeletal muscle cell biomass generation. The first aim of this study was therefore to identify enzymes tha...

2025-03-21 | MTBLS8854 | MetaboLights
UnknownAutophagy in muscle of glucose-infusion hyperglycemia rats and streptozotocin-induced hyperglycemia rats via selective activation of m-TOR or FoxO3.
Not available
S-EPMC3911944 | biostudies-literature
UnknownA novel palmitic acid hydroxy stearic acid (5-PAHSA) plays a neuroprotective role by inhibiting phosphorylation of the m-TOR-ULK1 pathway and regulating autophagy.
Not available
S-EPMC7941174 | biostudies-literature
UnknownBone morphogenetic protein 9 enhances osteogenic and angiogenic responses of human amniotic mesenchymal stem cells cocultured with umbilical vein endothelial cells through the PI3K/AKT/m-TOR signaling pathway.
Not available
S-EPMC8660623 | biostudies-literature
ProteomicsThe non-radioactive SUnSET assay to measure glucose-induced protein synthesis in human β-cells
Glucose regulates the expression of a limited number of genes in human pancreatic β-cells at the transcriptional level. Here, we asked whether glucose intervenes at post-transcriptional steps and regulates protein translation in human β-cell lines. First, we showed the involvement of the m-TOR pathw...
ORGANISM(S): Homo sapiens (Human) 
2021-07-27 | PXD023996 | Pride
Glucose regulation M-tor pathway Sunset Puromycin 
UnknownCo-administration strategy to enhance brain accumulation of vandetanib by modulating P-glycoprotein (P-gp/Abcb1) and breast cancer resistance protein (Bcrp1/Abcg2) mediated efflux with m-TOR inhibitors.
Not available
S-EPMC3402233 | biostudies-literature
UnknownThymoquinone Potentiates the Effect of Phenytoin against Electroshock-Induced Convulsions in Rats by Reducing the Hyperactivation of m-TOR Pathway and Neuroinflammation: Evidence from In Vivo, In Vitro and Computational Studies.
Not available
S-EPMC8618888 | biostudies-literature
UnknownLactate regulates autophagy through ROS-mediated activation of ERK1/2/m-TOR/p-70S6K pathway in skeletal muscle.
Not available
S-EPMC7905011 | biostudies-literature
UnknownALDH3A2 targets arachidonic acid to promote cell metastasis in TNBC via AMPK/m-TOR signaling pathway.
Not available
S-EPMC12715930 | biostudies-literature
TranscriptomicsDevelopment of Pathway Preferential Estrogens Affording Beneficial Metabolic and Vascular Actions without Reproductive Tissue Stimulation in Mice
There is great medical need for estrogens having favorable pharmacological profiles, supporting desirable activities for menopausal women such as metabolic and vascular protection but lacking stimulatory activities on the breast or uterus. Here, we report the development of structurally novel estrog...
ORGANISM(S): Homo sapiens 
2016-07-20 | E-GEOD-73663 | biostudies-arrayexpress
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