Sort   by:  
 Page size 
ProteomicsThe E3 ubiquitin ligase FBXL18 stabilizes BST2 to promote inflammation in RABV-infected astrocytes
we identify the ubiquitnation sites of BST2 and used quantitative proteomic analysis to compare protein abundance between WT MA-C cells and those that have received FBXL18-specific siRNAs
ORGANISM(S): Mus musculus (Mouse) 
2025-12-29 | PXD058432 | Pride
Bst2 ubiquitination，fbxl18 proteomics 
MetabolomicsSalmonella Typhimurium reprograms macrophage metabolism via T3SS effector SopE2 to promote intracellular replication and virulence

Salmonella Typhimurium establishes systemic infection by replicating in host macrophages. Here we show that macrophages infected with S. Typhimurium exhibit upregulated glycolysis and decreased serine synthesis, leading to accumulation of glycolytic intermediates. The effects on...

2024-05-22 | MTBLS2347 | MetaboLights
ProteomicsHuman intestine LC-MSMS - Transcriptional and proteomic analysis revealed a synergistic effect of aflatoxin M1 and ochratoxin A mycotoxins on intestinal epithelial integrity of differentiated human Caco-2 cells
Aflatoxin M1 (AFM1) is a common mycotoxin in dairy milk and it is typically concurrently present with other mycotoxins that may represent a threat for food safety. However, knowledge on how AFM1, alone or in combination with other mycotoxins may affect human intestinal epithelial integrity remain to...
ORGANISM(S): Homo sapiens (Human) 
2018-08-08 | PXD009437 | Pride
Human Intestinal epithelial cells Lc-msms 
ProteomicsMass spectrometry analysis of RSV-induced RAW264.7 cells
In order to further explore the expression of proteins in RSV-infected macrophages, RSV type-L19 was used to stimulate RAW264.7 cells, and then mass spectrometry was conducted to detect the expression of different proteins after RSV infection. The results showed that there were different expression ...
ORGANISM(S): Mus musculus (Mouse) 
2023-05-26 | PXD042041 | Pride
Mass spectrometry analysis Rsv Raw264.7 cells 
ProteomicsThe analysis of RhMYB73-interacted proteins in rose by LC-MS
The size of plant lateral organs is determined by well-coordinated cell proliferation and cell expansion. Here, we report that miR159, an evolutionarily conserved microRNA, plays an essential role in regulating cell division in rose (Rosa hybrida) petals by modulating cytokinin catabolism. We uncove...
ORGANISM(S): Rosa Hybrid Cultivar 
PXD046197 |
ProteomicsChronotoxici-plate Containing Rhythmic Liver Organoids for Drug Screening
The circadian clock coordinates the daily rhythmicity of biological processes, and its dysregulation is associated with various human diseases. Despite the direct targeting of rhythmic genes by many best-selling and WHO essential drugs, traditional approaches can’t satisfy the need of explore multi-...
ORGANISM(S): Mus Musculus 
PXD043268 |
ProteomicsAn integrative multi-omics approach uncovers the regulatory role of Cdk7 and Cdk4 in autophagy induced by silica nanoparticles
The abnormal induction of macroautophagy/autophagy, a highly conserved lysosome-based degradation pathway, has been postulated as a major toxicity of nanomaterials, whereas little is known on the exact molecular mechanisms. Here, we treated mammalian cells with 16 nm silica nanoparticles (SiNPs), co...
ORGANISM(S): Rattus Norvegicus 
2019-12-01 | PXD012196 |
ProteomicsHippocampal subfields proteome analysis and comparation in Alzheimer’s disease providing new sight on glia function
The hippocampus and entorhinal cortex are the earliest areas affected by AD pathology, which are related to early memory loss in patients. The hippocampus subfields are heterogeneous, with different order and degree affect by AD pathology. Studying the molecular changes may explain the difference, a...
ORGANISM(S): Homo Sapiens 
2021-07-16 | PXD027380 |
MetabolomicsVGLL4 modulates Paneth cells and sustains intestinal homeostasis.
Paneth cells are defensive cells in the intestinal tract, which secrete niche factors and antimicrobial peptides (AMPs) to maintain the small intestinal stem cell niche and immune homeostasis. Here, we show that Vestigial-like family member 4 (VGLL4) plays a pivotal role in maintaining small intesti...
2026-03-12 | MTBLS10456 | MetaboLights
UnknownRobust estimation of bacterial cell count from optical density.
Not available
S-EPMC7499192 | biostudies-literature
Sort   by:  
 Page size