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MetabolomicsMaslinic acid-enriched diet decreases intestinal tumorigenesis in Apc(Min/+) mice through transcriptomic and metabolomic reprogramming
Chemoprevention is a pragmatic approach to reduce the risk of colorectal cancer, one of the leading causes of cancer-related death in western countries. In this regard, maslinic acid (MA), a pentacyclic triterpene extracted from wax-like coatings of olives, is known to inhibit proliferation and indu...
2017-02-09 | MTBLS240 | MetaboLights
Unknown"Nine Dimensions": A multidisciplinary approach for community engagement in a complex postwar border region as part of the targeted malaria elimination in Karen/Kayin State, Myanmar.
Not available
S-EPMC6343222 | biostudies-literature
TranscriptomicsTranscription profilfing of human cerebrovascular smooth muscle to identify Ca2+-dependent transcription patterns
Altered Ca2+ handling has both immediate physiological effects and long-term genomic effects on vascular smooth muscle function. Previously we have shown that elevation of cytoplasmic Ca2+ through voltage-dependent Ca2+ channels (VDCCs) or store-operated Ca2+ channels (SOCCs) results in phosphoryla...
ORGANISM(S): Homo sapiens 
2009-04-29 | E-GEOD-2883 | biostudies-arrayexpress
MetabolomicsMetabonomics uncovers a reversible proatherogenic lipid profile during infliximab therapy of inflammatory bowel disease

BACKGROUND: One-third of inflammatory bowel disease (IBD) patients show no response to infliximab (IFX) induction therapy, and approximately half of patients responding become unresponsive over time. Thus, identification of potential treatment response biomarkers are of great cl...

2022-01-13 | MTBLS239 | MetaboLights
UnknownComputerized Cognitive Training for Amelioration of Cognitive Late Effects Among Childhood Cancer Survivors: A Randomized Controlled Trial.
Not available
S-EPMC4652013 | biostudies-literature
MetabolomicsPlasma metabolic profile in COPD patients: effects of exercise and endurance training
The study examines plasma metabolic profiles of patients with chronic obstructive pulmonary disease (COPD) to prove whether the disease influences metabolism at rest and after endurance training. This is based on the hypothesis that metabolome levels should reflect impaired skeletal muscle bioenerge...
2017-03-10 | MTBLS249 | MetaboLights
UnknownPreserved collagen reveals species identity in archaeological marine turtle bones from Caribbean and Florida sites.
Not available
S-EPMC6837194 | biostudies-literature
TranscriptomicsGenome-wide analysis reveals conserved transcriptional responses downstream of resting potential change in Xenopus embryos, axolotl regeneration, and human mesenchymal cell differentiation [frog data]
Endogenous bioelectric signaling via changes in cellular resting potential (Vmem) is a key regulator of patterning during regeneration and embryogenesis in numerous model systems. Depolarization of Vmem has been functionally implicated in de-differentiation, tumorigenesis, anatomical re-specificatio...
ORGANISM(S): Xenopus laevis 
2016-07-03 | E-GEOD-72097 | biostudies-arrayexpress
TranscriptomicsBowel expression profiles of infants with gastrointestinal conditions
We have employed whole genome microarray expression profiling to identify genes differentially expressed in neonatal bowel tissues of different gastrointestinal conditions. Bowel tissues were collected from infants who underwent surgery treatment for necrotising enterocolitis (NEC) and spontaneous i...
ORGANISM(S): Homo sapiens 
2014-01-21 | E-GEOD-46619 | biostudies-arrayexpress
ProteomicsBiochemical Foundations of Health and Energy Conservation in Hibernating Free-Ranging Subadult Brown Bear Ursus arctos
Brown bears (Ursus arctos) hibernate for 5-7 months without eating, drinking, urinating and defecating at a metabolic rate of only 25% of the summer activity rate. Nonetheless, they emerge healthy and alert in spring. We analyzed the physiological adaptations for hibernation by comparing the proteom...
ORGANISM(S): Ursus arctos arctos (European brown bear) 
2016-09-27 | PXD003946 | Pride
Ursus arctos Brown bear Proteomics Hibernation Lc-ms/ms 
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