Sort   by:  
 Page size 
TranscriptomicsRibosome hibernation factor promotes Staphyloccocal survival and differentially represses translation
We sequenced a total of 16 cDNA libararies derived from fragmented total mRNA and ribosome protected mRNAs from S. aureus hpf mutant (NE838) and its parental strain JE2 grown in tryptic soy broth (TSB) or minimal medium (MM). The data represented 2 independent biological replicates. Examination of t...
ORGANISM(S): Staphylococcus aureus 
2016-03-29 | E-GEOD-74197 | biostudies-arrayexpress
TranscriptomicsRNASeq analysis of brown bear (Ursus arctos) skin tissue during active state and hibernation
Transcriptomic analysis of the brown bear (Ursus arctos) tissues during both active and inactive phases has unveiled significant differential gene expression, with thousands of genes exhibiting altered activity in all studied tissues (muscle, liver, adipose...). Nevertheless, transcriptional analyse...
ORGANISM(S): Ursus arctos 
2025-09-05 | E-MTAB-14479 | biostudies-arrayexpress
ProteomicsQuantitative proteomics of brown bear muscle during hibernation
During hibernation, the physiology of bears is characterized by strong metabolic depression. In skeletal muscles, lipids are used as the main energy fuels although their oxidation rate is reduced, and glycolysis appears maintained likely feeding the Cori cycle. For a better knowledge on proteome rem...
ORGANISM(S): Ursus arctos (Brown bear) (Grizzly bear) 
2026-03-02 | PXD060503 | Pride
Lc-msms Metabolic depression Bear Hibernation Muscle 
TranscriptomicsAnalysis of molecular signatures in mammalian hibernation
Mammalian hibernators display phenotypes similar to physiological conditions in non-hibernating species under conditions of calorie restriction and fasting, hypoxia, hypothermia, ischemia-reperfusion, and sleep. However, whether or how similarities are also reflected on molecular and genetic levels ...
ORGANISM(S): Urocitellus parryii 
2012-09-01 | E-GEOD-38700 | biostudies-arrayexpress
ProteomicsLC-MSMS analysis of bear muscle mitochondria during hibernation
During hibernation, the physiology of bears is characterized by strong metabolic depression. In skeletal muscles, lipids are used as the main energy fuels although their oxidation rate is reduced, and glycolysis appears maintained likely feeding the Cori cycle. Mitochondria no doubt play an essentia...
ORGANISM(S): Ursus arctos arctos (European brown bear) 
2026-03-02 | PXD036916 | Pride
Lc-msms Metabolic depression Temperature Bear Hibernation 
ProteomicsA new family of ribosome hibernation factors in ArchaeaA new family of ribosome hibernation factors in Archaea
Ribosome hibernation preserves translation machinery during stress, yet its mechanisms in Archaea remain poorly defined. Here, we identify HibA, a previously unrecognized family of hibernation factors widespread in Archaea. HibA consists of a bacterial-like HPF/RaiA domain fused to a Cystathionine B...
ORGANISM(S): Pyrococcus abyssi GE5 
2026-03-24 | PXD073243 | Pride
Archaea Ribosome Hibernation 
TranscriptomicsGene Expression Data of Hibernating and Summer Active Black Bears
We conducted a large-scale gene expression screen using the 3,200 cDNA probe microarray developed specifically for Ursus americanus to detect expression differences in liver and skeletal muscle that occur during winter hibernation in comparison to animals sampled during summer. The expression of 12 ...
ORGANISM(S): Ursus americanus 
2009-03-09 | E-GEOD-15099 | biostudies-arrayexpress
TranscriptomicsmiRNA profiling by Agilent mouse miRNA microarray
miRNAs are 19-25 nucleotides long small RNAs now well-known for their regulatory roles in the development and diseases through post-transcriptional and translational controls in a wide range of species. Mammalian hibernation is a physiological process involving dramatic metabolic suppression and cel...
ORGANISM(S): Urocitellus parryii 
2010-11-30 | E-GEOD-19427 | biostudies-arrayexpress
ProteomicsCharacterizing cardiac molecular mechanisms of mammalian hibernation via quantitative proteogenomics.
This study uses advanced proteogenomic approaches in a non-model organism to elucidate cardioprotective mechanisms used during mammalian hibernation. Mammalian hibernation is characterized by dramatic reductions in body temperature, heart rate, metabolism and oxygen consumption. These changes pose s...
ORGANISM(S): Spermophilus tridecemlineatus (Thirteen-lined ground squirrel) 
2015-11-03 | PXD002457 | Pride
Keywords: proteogenomics Heart. Galaxy-p Hibernation 
ProteomicsResting skeletal muscle reduces ATP turnover during hibernation
In mammals, loss of food intake and reduced mechanical loading/activity of skeletal muscles leads to a very rapid loss in mass and function. However, during hibernation in bears, despite spending months without feeding and with very modest muscle activity, only moderate muscle wasting is observed. P...
ORGANISM(S): Ursus arctos (Brown bear) (Grizzly bear) 
2024-12-06 | PXD050980 | Pride
Bear Hibernation Skinned muscle fibers Single muscle fiber 
Sort   by:  
 Page size