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TranscriptomicsRNASeq analysis of brown bear (Ursus arctos) skin tissue during active state and hibernation
Transcriptomic analysis of the brown bear (Ursus arctos) tissues during both active and inactive phases has unveiled significant differential gene expression, with thousands of genes exhibiting altered activity in all studied tissues (muscle, liver, adipose...). Nevertheless, transcriptional analyse...
ORGANISM(S): Ursus arctos 
2025-09-05 | E-MTAB-14479 | biostudies-arrayexpress
ProteomicsBiochemical Foundations of Health and Energy Conservation in Hibernating Free-Ranging Subadult Brown Bear Ursus arctos
Brown bears (Ursus arctos) hibernate for 5-7 months without eating, drinking, urinating and defecating at a metabolic rate of only 25% of the summer activity rate. Nonetheless, they emerge healthy and alert in spring. We analyzed the physiological adaptations for hibernation by comparing the proteom...
ORGANISM(S): Ursus arctos arctos (European brown bear) 
2016-09-27 | PXD003946 | Pride
Ursus arctos Brown bear Proteomics Hibernation Lc-ms/ms 
ProteomicsQuantitative proteomics of brown bear muscle during hibernation
During hibernation, the physiology of bears is characterized by strong metabolic depression. In skeletal muscles, lipids are used as the main energy fuels although their oxidation rate is reduced, and glycolysis appears maintained likely feeding the Cori cycle. For a better knowledge on proteome rem...
ORGANISM(S): Ursus arctos (Brown bear) (Grizzly bear) 
2026-03-02 | PXD060503 | Pride
Lc-msms Metabolic depression Bear Hibernation Muscle 
Proteomics,MultiomicsProteomic and Transcriptomic Changes in Hibernating Grizzly Bears Reveal Metabolic and Signaling Pathways that Protect against Muscle Atrophy
Muscle atrophy is a physiological response to disuse and malnutrition, but hibernating bears are largely resistant to this phenomenon. Unlike other mammals, they efficiently reabsorb amino acids from urine, periodically activate muscle contraction, and their adipocytes differentially responds to ins...
ORGANISM(S): Ursus Arctos Horribilis (ncbitaxon:116960) 
2020-01-06 | MSV000084760 | MassIVE
TranscriptomicsPrenatal arsenic exposure and the epigenome: altered miRNA expression profiles in newborn cord blood
The Biomarkers of Exposure to ARsenic (BEAR) pregnancy cohort in Gómez Palacio, Mexico was recently established to better understand the impacts of prenatal exposure to inorganic arsenic (iAs). In this study, we examined a subset (n = 40) of newborn cord blood samples for microRNA (miRNA) expression...
ORGANISM(S): Homo sapiens 
2014-01-22 | E-GEOD-48353 | biostudies-arrayexpress
ProteomicsLC-MSMS analysis of HFF1 cells exposed to bear and bovine serum
The serum of hibernating bears has been shown to exhibit cytoprotective, anticatabolic effects when applied to human or mouse skeletal muscle cells. It is also able to reduce mitochondrial respiration in cells obtained from bear adipose tissue. Its action notably might involve reprogramming of trans...
ORGANISM(S): Homo sapiens (Human) 
2025-12-08 | PXD069199 | Pride
Serum Hibernation Quantitative proteomics Fibroblast 
ProteomicsBrown bear skeletal muscle quantitative LC-MSMS
Muscle atrophy is one of the main deleterious consequences of ageing and physical inactivity. Although basic knowledge regarding the underlying mechanisms of muscle atrophy is continuously growing, there are still no efficient therapeutic strategies for its prevention and treatment. Hibernating bear...
ORGANISM(S): Ursus arctos (Brown bear) (Grizzly bear) 
2019-05-14 | PXD004908 | Pride
Lc-msms Skeletal muscle Hibernation Bears 
Genomicsbear fecal FMT mice
bear fecal FMT mice Raw sequence reads
PRJNA1260068 | ENA
UnknownDesign Features and Rationale of the BEAR-MOON (Bridge-Enhanced ACL Restoration Multicenter Orthopaedic Outcomes Network) Randomized Clinical Trial.
Not available
S-EPMC8793429 | biostudies-literature
ProteomicsLC-MSMS analysis of bear muscle mitochondria during hibernation
During hibernation, the physiology of bears is characterized by strong metabolic depression. In skeletal muscles, lipids are used as the main energy fuels although their oxidation rate is reduced, and glycolysis appears maintained likely feeding the Cori cycle. Mitochondria no doubt play an essentia...
ORGANISM(S): Ursus arctos arctos (European brown bear) 
2026-03-02 | PXD036916 | Pride
Lc-msms Metabolic depression Temperature Bear Hibernation 
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