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MetabolomicsAntibiotics create a shift from mutualism to competition in human gut communities with a longer-lasting impact on fungi than bacteria

Background

Antibiotic treatment has a well-established detrimental effect on the gut bacterial composition, but effects on the fungal community are less clear. Bacteria in the lumen of the gastrointestinal tract may limit fungal colonization and invasion. Antibiotic drugs t...

2020-09-28 | MTBLS1846 | MetaboLights
MetabolomicsAngiopoietin-like 4 governs diurnal lipoprotein lipase activity in brown adipose tissue.

OBJECTIVE: Brown adipose tissue (BAT) burns fatty acids (FAs) to produce heat, and shows diurnal oscillation in glucose and triglyceride (TG)-derived FA-uptake, peaking around wakening. Here we aimed to gain insight in the diurnal regulation of metabolic BAT activity.

2023-11-15 | MTBLS4082 | MetaboLights
UnknownMedial septal GABAergic neurons reduce seizure duration upon optogenetic closed-loop stimulation.
Not available
S-EPMC8219369 | biostudies-literature
UnknownMaternal Mediterranean-Style Diet Adherence during Pregnancy and Metabolomic Signature in Postpartum Plasma: Findings from the Boston Birth Cohort.
Not available
S-EPMC10942856 | biostudies-literature
TranscriptomicsRainbow trout red blood cells (RBCs): Control vs Heat shock, repeated samples from individuals
The retention of a nucleus in the mature state of fish red blood cells (RBCs), and the ability to easily collect and manipulate blood in non-terminal experiments, makes it an ideal tissue on which to study the cellular stress response in fish. Through the use of the cGRASP 16K salmonid microarray, w...
ORGANISM(S): Oncorhynchus mykiss 
2010-09-21 | E-GEOD-21084 | biostudies-arrayexpress
TranscriptomicsGranulosa cell differentiation in vivo and developmental competence of oocytes in the bovine model
Transcriptional profiling of in vivo granulosa cells collected at 20h, 44h, 68h, and 92h of coasting in lactating cow (breed Holstein) 4 conditions experiment, 3 biological replicates, one repliacte per array, dye swap experiment, two colors, 20h vs 44h, 44h vs 68h, 68h vs 92h, 20h vs 68h, 20h vs 92...
ORGANISM(S): Bos taurus 
2013-06-03 | E-GEOD-40916 | biostudies-arrayexpress
MetabolomicsComprehensive systems biology analysis of a seven-month cigarette smoke inhalation study in C57BL/6 mice
Smoking of combustible cigarettes has a major impact on human health. Using a systems toxicology approach in a model of chronic obstructive pulmonary disease (C57BL/6 mice), we assessed the health consequences in mice of smoke derived from a prototype modified risk tobacco product (pMRTP) as compare...
2015-11-19 | MTBLS143 | MetaboLights
TranscriptomicsIntegrative genomic, transcriptomic and RNAi analysis indicates a potential oncogenic role for FAM110B in castration-resistant prostate cancer.
Background: Castration-resistant prostate cancer (CRPC) represents a therapeutic challenge for current medications. Methods: In order to explore the molecular mechanisms involved in CRPC progression and to identify new therapeutic targets, we analyzed a unique sample set of 11 castration-resistant p...
ORGANISM(S): Homo sapiens 
2011-08-28 | E-GEOD-28403 | biostudies-arrayexpress
MetabolomicsExpanding the clinical use of DBS: through a metabolomic and a lipidomic evaluation

Personalized medicine aims to tailor healthcare to individual characteristics, relying on precise biological data and patient monitoring. Metabolomics and lipidomics play a key role in this approach, providing real-time insights into metabolic states and enabling accurate diagnosis and treatment ...

2026-02-25 | MTBLS13382 | MetaboLights
UnknownPlasma AR Alterations and Timing of Intensified Hormone Treatment for Prostate Cancer: the STAMPEDE Phase 3 Randomized Clinical Trial.
Not available
S-EPMC11869088 | biostudies-literature
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