Serum Proteomic and Metabolomic Profiling of Sepsis Patients Reveals a Diagnostic Model and Mechanistic Insights into Carbapenem-Resistant Klebsiella pneumoniae Infection
Responses to drought in rice are regulated by transcription factor OsbZIP46 via ABA signaling. This work characterizes a protein MODD that negatively regulates OsbZIP46 activity and stability through HDAC-related chromatin remodeling and OsPUB70-mediated ubiquitination, respectively, to fine tune AB...
Urine is an ideal material to study and examine the bladder cancer (BCa) biomarkers, whereas exploration to the corresponding protein candidates is confronting technique challenges. Herein, we proposed a comprehensive strategy of searching the urine proteins related to BCa. The strategy consists of ...
The outbreak of coronavirus disease 2019 (COVID-19) is a global health emergency. Various omics results have been reported for COVID-19, but the molecular hallmarks of COVID-19, especially in those patients without comorbidities, have not been fully investigated. Here we collect blood samples from 2...
We propose that enrichment of low-abundance proteins benefits MPs finding. ProteoMinerTM is an equalizing technique by reducing high-abundance proteins and enriching low-abundance proteins in biological liquids. With triton X-100/TBS buffer extraction, ProteoMinerTM enrichment and peptide fractionat...
2 g developing siliques were harvested from the pMYB5:MYB5-GFP/myb5-2 complementary plants treated with 100 μM GA3 or 50 μM PAC. The 35S:GFP transgenic plants served as a negative control. Siliques were immediately crosslinked with 1% paraformaldehyde for 30 min on ice in a vacuum chamber. Total pro...