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MetabolomicsExcoriation Disorder Is Characterized by Systemic Glutamatergic Dysfunction

Excoriation disorder (ED), also known as neurotic excoriations, is a psychocutaneous disorder characterized by repetitive, compulsive picking of the skin leading to secondary tissue damage. ED carries an estimated prevalence of 1.4%, and is associated with significant social dysfunction, as patie...

2024-04-03 | MTBLS9118 | MetaboLights
ProteomicsNuclear HMGB1 is critical for CD8 T cell IFN-g production and anti-tumor immunity
HMGB1 has been extensively studied as a DAMP, with secreted cytokine function. However, its regulation on T cells, especially the function in the nucleus, has not been elucidated. Here, we extracted the total protein of CD8 T cells and enriched the proteins bound to HMGB1 through IP experiment. We...
ORGANISM(S): Mus Musculus 
2024-03-15 | PXD050639 |
MetabolomicsCancer-cell-secreted exosomal miR-105 promotes tumour growth through the Myc-dependent metabolic reprogramming of stromal cells
Cancer and other cells residing in the same niche engage various modes of interactions to synchronize and to buffer the negative effects of environmental changes. Extracellular miRNAs have been recently implicated in the intercellular crosstalk. Here we show a mechanistic model involving breast-canc...
2018-07-10 | MTBLS626 | MetaboLights
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