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UnknownDNA sequence+shape kernel enables alignment-free modeling of transcription factor binding.
Not available
S-EPMC5870879 | biostudies-literature
GenomicsGenome-wide maps of Six2 and b-catenin in mesenchymal nephron progenitors
Self-renewing undifferentiated nephron progenitors express Six2, a transcription factor that is required for their maintenance as undifferentiated progenitors. Differentiation of nephron progenitors is triggered by Wnt/b-catenin signaling. In order to understand how Six2 and Wnt signaling counteract...
ORGANISM(S): Mus musculus 
2012-09-11 | E-GEOD-39837 | biostudies-arrayexpress
TranscriptomicsTranscriptional response of cap mesenchyme (undifferentiated nephron progenitors) to Wnt activation
During mammalian kidney development, mesenchymal nephron progenitors (cap mesenchyme) differentiate into the epithelial cells that go on to form the nephron. Although differentiation of nephron progenitors is triggered by activation of Wnt/b-catenin signaling, constitutive activation of Wnt/b-cateni...
ORGANISM(S): Mus musculus 
2012-09-11 | E-GEOD-39583 | biostudies-arrayexpress
UnknownThe lncRNA Firre anchors the inactive X chromosome to the nucleolus by binding CTCF and maintains H3K27me3 methylation.
Not available
S-EPMC4391730 | biostudies-literature
TranscriptomicsEscape from X inactivation in mouse tissues (RNA-Seq)
X chromosome inactivation (XCI) silences most genes on one X chromosome in female mammals, but some genes escape XCI. To identify escape gene in vivo and to explore molecular mechanisms that regulate this process we analyzed the allele-specific expression and chromatin structure of X-linked genes in...
ORGANISM(S): Mus musculus x Mus spretus 
2015-02-20 | E-GEOD-59777 | biostudies-arrayexpress
TranscriptomicsEffects of Firre knockdown on mouse gene expression
In mammals, genes located on the X chromosome are present in one copy in XY males and two in XX females. To balance the dosage of X-linked gene expression between the sexes one of the two X chromosomes in females is silenced by X inactivation initiated by up-regulation of the lncRNA (long non-coding...
ORGANISM(S): Mus musculus x Mus spretus 
2015-03-05 | E-GEOD-66172 | biostudies-arrayexpress
GenomicsAllele-specific maps of RNA polymerase II phosphorylated at serine 5 in mouse cultured hybrid cells and mouse hybrid brain
We report the application of single-molecule-based sequencing technology for high-throughput profiling of RNA polymerase II phosphorylated at serine 5 (PolII-S5p; the transcription initiation form) in female mouse cultured hybrid cells and female hybrid brain derived from mouse systems with skewed X...
ORGANISM(S): Mus musculus x Mus spretus 
2013-02-15 | E-GEOD-44255 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse skin after acute withdrawal of TERT
TERT is an essential protein component of telomerase, a ribonuclearprotein complex that protects chromosomal ends. Ectopic expression of TERT in mouse skin activates hair follicle stem cells and induces active growth phase of hair cycles, called anagen. This activity of TERT is independent of its re...
ORGANISM(S): Mus musculus 
2008-06-17 | E-GEOD-9725 | biostudies-arrayexpress
GenomicsEscape from X inactivation in mouse tissues (ChIP-Seq)
X chromosome inactivation (XCI) silences most genes on one X chromosome in female mammals, but some genes escape XCI. To identify escape gene in vivo and to explore molecular mechanisms that regulate this process we analyzed the allele-specific expression and chromatin structure of X-linked genes in...
ORGANISM(S): Mus musculus x Mus spretus 
2015-02-20 | E-GEOD-59778 | biostudies-arrayexpress
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