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GenomicsDerivation of pre-X inactivation human embryonic stem cells under physiological oxygen concentrations
The presence of two active X chromosomes (XaXa) is a hallmark of the ground state of pluripotency specific to murine embryonic stem cells (ESCs). Human ESCs invariably exhibit signs of X chromosome inactivation (XCI) and are considered developmentally more advanced than their murine counterparts. W...
ORGANISM(S): Homo sapiens 
2010-05-28 | E-GEOD-21141 | biostudies-arrayexpress
UnknownA mixed modality approach towards Xi reactivation for Rett syndrome and other X-linked disorders.
Not available
S-EPMC5789928 | biostudies-literature
TranscriptomicsX-chromosome inactivation in monkey embryos and pluripotent stem cells
In this study, we explored x-inactivation in monkey embryos (ICM and TE separately) and pluripotent stem cells (IVF derived ES, SCNT-derived ES and monkey iPS) To elucidate x-inactivation in experimentally reprogrammed pluripotent cells, we derived pluripotent stem cells by both SCNT and iPS approac...
ORGANISM(S): Macaca mulatta 
2012-08-31 | E-GEOD-36252 | biostudies-arrayexpress
TranscriptomicsEscape from X inactivation in mouse tissues (RNA-Seq)
X chromosome inactivation (XCI) silences most genes on one X chromosome in female mammals, but some genes escape XCI. To identify escape gene in vivo and to explore molecular mechanisms that regulate this process we analyzed the allele-specific expression and chromatin structure of X-linked genes in...
ORGANISM(S): Mus musculus x Mus spretus 
2015-02-20 | E-GEOD-59777 | biostudies-arrayexpress
GenomicsEscape from X inactivation in mouse tissues (ChIP-Seq)
X chromosome inactivation (XCI) silences most genes on one X chromosome in female mammals, but some genes escape XCI. To identify escape gene in vivo and to explore molecular mechanisms that regulate this process we analyzed the allele-specific expression and chromatin structure of X-linked genes in...
ORGANISM(S): Mus musculus x Mus spretus 
2015-02-20 | E-GEOD-59778 | biostudies-arrayexpress
UnknownSelective Xi reactivation and alternative methods to restore MECP2 function in Rett syndrome.
Not available
S-EPMC9915138 | biostudies-literature
UnknownQuantitatively imaging chromosomes by correlated cryo-fluorescence and soft x-ray tomographies.
Not available
S-EPMC4213715 | biostudies-literature
UnknownThe human inactive X chromosome modulates expression of the active X chromosome.
Not available
S-EPMC9932992 | biostudies-literature
UnknownStable and robust Xi and Y transcriptomes drive cell-type-specific autosomal and Xa responses in vivo and in vitro in four human cell types.
Not available
S-EPMC11480847 | biostudies-literature
UnknownThe human Y and inactive X chromosomes similarly modulate autosomal gene expression.
Not available
S-EPMC10794785 | biostudies-literature
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