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GenomicsDerivation of pre-X inactivation human embryonic stem cells under physiological oxygen concentrations
The presence of two active X chromosomes (XaXa) is a hallmark of the ground state of pluripotency specific to murine embryonic stem cells (ESCs). Human ESCs invariably exhibit signs of X chromosome inactivation (XCI) and are considered developmentally more advanced than their murine counterparts. W...
ORGANISM(S): Homo sapiens 
2010-05-28 | E-GEOD-21141 | biostudies-arrayexpress
UnknownA mixed modality approach towards Xi reactivation for Rett syndrome and other X-linked disorders.
Not available
S-EPMC5789928 | biostudies-literature
TranscriptomicsX-chromosome inactivation in monkey embryos and pluripotent stem cells
In this study, we explored x-inactivation in monkey embryos (ICM and TE separately) and pluripotent stem cells (IVF derived ES, SCNT-derived ES and monkey iPS) To elucidate x-inactivation in experimentally reprogrammed pluripotent cells, we derived pluripotent stem cells by both SCNT and iPS approac...
ORGANISM(S): Macaca mulatta 
2012-08-31 | E-GEOD-36252 | biostudies-arrayexpress
ProteomicsSirtuin 7 regulates Xa-hyperactivation to balance the X-chromosome against the genome
Sirtuins are deacetylases implicated in stress responses and longevity in mammals. Although their differential impact on the two sexes has been noted, underlying causes for sex biases in aging and cancer are not known. Here, using Sirtuin 7 (SIRT7) as a model in mice, we probe mechanisms leading to ...
ORGANISM(S): Mus musculus (Mouse) 
2026-03-27 | PXD057198 | Pride
Sirt7 Label free Acetylation X-chromosome Phosphorylation Maxquant Ezh2 Sirtuin 7 
TranscriptomicsEscape from X inactivation in mouse tissues (RNA-Seq)
X chromosome inactivation (XCI) silences most genes on one X chromosome in female mammals, but some genes escape XCI. To identify escape gene in vivo and to explore molecular mechanisms that regulate this process we analyzed the allele-specific expression and chromatin structure of X-linked genes in...
ORGANISM(S): Mus musculus x Mus spretus 
2015-02-20 | E-GEOD-59777 | biostudies-arrayexpress
GenomicsEscape from X inactivation in mouse tissues (ChIP-Seq)
X chromosome inactivation (XCI) silences most genes on one X chromosome in female mammals, but some genes escape XCI. To identify escape gene in vivo and to explore molecular mechanisms that regulate this process we analyzed the allele-specific expression and chromatin structure of X-linked genes in...
ORGANISM(S): Mus musculus x Mus spretus 
2015-02-20 | E-GEOD-59778 | biostudies-arrayexpress
UnknownSelective Xi reactivation and alternative methods to restore MECP2 function in Rett syndrome.
Not available
S-EPMC9915138 | biostudies-literature
UnknownQuantitatively imaging chromosomes by correlated cryo-fluorescence and soft x-ray tomographies.
Not available
S-EPMC4213715 | biostudies-literature
UnknownThe human inactive X chromosome modulates expression of the active X chromosome.
Not available
S-EPMC9932992 | biostudies-literature
UnknownStable and robust Xi and Y transcriptomes drive cell-type-specific autosomal and Xa responses in vivo and in vitro in four human cell types.
Not available
S-EPMC11480847 | biostudies-literature
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