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GenomicsAntitumor immunity induced by antibody-based natural killer cell engager therapeutics armed with not-alpha IL-2 variant
Antitumor immunity induced by antibody-based natural killer cell engager therapeutics armed with not-alpha IL-2 variant
PRJNA885093 | ENA
ProteomicsQuantitative Host Cell Protein Analysis across Innovator Monoclonal Antibody-Based Protein Therapeutics using the Orbitrap Astral Mass Spectrometer
Protein biotherapeutics such as monoclonal antibodies (mAbs) are generally produced using cell-based production systems that generate endogenous proteins, commonly referred to as host cell proteins (HCPs), along with the desired drug products. A critical challenge is the removal of HCPs from the fin...
ORGANISM(S): Mus musculus (Mouse) Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus) 
2026-04-20 | PXD067004 | Pride
Host cell proteins Mab based therapeutics Orbitrap astral ms Mass spectrometry 
ProteomicsHighly selective humanized DDR1 mAb reverses immune exclusion by disrupting collagen fiber alignment in breast cancer
Discoidin domain-containing receptor 1 (DDR1) plays an important role in cancer progression. However, the DDR1 function in tumors is still elusive. We recently reported that DDR1 promoted collagen fiber alignment and formation of a physical barrier, which causes immune exclusion from tumors. We also...
ORGANISM(S): Homo sapiens (Human) 
2023-06-19 | PXD042971 | Pride
Ddr1 Breast cancer Prth-101 Hdx-ms Mab 
UnknownAntibody-based therapeutics to watch in 2011.
Not available
S-EPMC3038014 | biostudies-literature
UnknownEvaluation of the potential impact of Ebola virus genomic drift on the efficacy of sequence-based candidate therapeutics.
Not available
S-EPMC4313914 | biostudies-literature
MetabolomicsStudy on the Hepatoprotection of Schisandra chinensis Caulis Ploysaccharides in nonalcoholic fatty liver disease in rats based on metabolomics

The aim of this study was to investigate the hepatoprotection of Schisandra chinensis Caulis polysaccharides (SCP) in the nonalcoholic fatty liver disease (NAFLD) induced by high-fat diet (HFD) in rats. A total of 30 Wistar rats were randomly divided into control group (CON), model group...

2021-08-24 | MTBLS3194 | MetaboLights
GenomicsAssessing biosimilarity of Trastuzumab monoclonal antibody therapeutics using RNA sequencing
Assessing biosimilarity of Trastuzumab monoclonal antibody therapeutics using RNA sequencing
PRJNA667165 | ENA
Unknown<i>In vitro</i> potency and pharmacokinetics of APG777, a novel anti-IL-13 mAb.
Not available
S-EPMC12419008 | biostudies-literature
UnknownMonoclonal antibody-based candidate therapeutics against HIV type 1.
Not available
S-EPMC3332369 | biostudies-literature
UnknownDevelopment of Antibody Therapeutics against Flaviviruses.
Not available
S-EPMC5796004 | biostudies-literature
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