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TranscriptomicsDDR1 knockdown in BXPC3 cell line
Examination of effect of stable DDR1 knockdown by shRNA on transcriptional profile in BXPC3 cell line to understand role of DDR1 in tumorigenesis. Transcriptional profiles of parental BXPC3 cell line was compared to BXPC3 cells stably transfected with non-target shRNA or DDR1 shRNA, N=3 for each con...
ORGANISM(S): Homo sapiens 
2014-05-01 | E-GEOD-39207 | biostudies-arrayexpress
ProteomicsIdentification of DDR1-interacting proteins by IP-MS screening
To investigate and identify the potential DUBs that stabilize and interact with DDR1, we performed immunoprecipitation of endogenous DDR1 with anti-DDR1 antibody (specific IP) or anti-IgG antibody (negative control) in A549 cells followed by mass spectrometry analysis.
ORGANISM(S): Homo sapiens (Human) 
2025-09-08 | PXD065332 | Pride
Ddr1 Ip-ms Co-immunoprecipitated proteins 
ProteomicsHighly selective humanized DDR1 mAb reverses immune exclusion by disrupting collagen fiber alignment in breast cancer
Discoidin domain-containing receptor 1 (DDR1) plays an important role in cancer progression. However, the DDR1 function in tumors is still elusive. We recently reported that DDR1 promoted collagen fiber alignment and formation of a physical barrier, which causes immune exclusion from tumors. We also...
ORGANISM(S): Homo sapiens (Human) 
2023-06-19 | PXD042971 | Pride
Ddr1 Breast cancer Prth-101 Hdx-ms Mab 
ProteomicsLC-MS/MS IP_DDR1 - Determine the relative abundance of proteins that associate with DDR1 when cells with different expression levels of DDR1 and lacking beta 1 integrins are cultured on collagen or on fibronectin
Determine the relative abundance of proteins that associate with DDR1 when cells with different expression levels of DDR1 and lacking beta 1 integrins are cultured on collagen or on fibronectin
ORGANISM(S): Mus musculus (Mouse) 
2017-02-03 | PXD005722 | Pride
Ddr1 Collagen Fibronectin 
ProteomicsIn vitro DDR1 signalling - Inhibition of DDR1-BCR signalling by nilotinib as a new therapeutic strategy for metastatic colorectal cancer
The clinical management of metastatic colorectal cancer (mCRC) faces major challenges. For instance, patients harbouring oncogenic mutations in RAS signalling do not respond to anti-EGFR targeted treatment. Therefore, RAS-independent therapies are needed. Interestingly nilotinib, a clinically approv...
ORGANISM(S): Homo sapiens (Human) 
2018-01-31 | PXD008582 | Pride
Signalling Metastatic colorectal cancer Ddr1 tyrosine kinase 
ProteomicsIn vivo DDR1 signalling - Inhibition of DDR1-BCR signalling by nilotinib as a new therapeutic strategy for metastatic colorectal cancer
The clinical management of metastatic colorectal cancer (mCRC) faces major challenges. For instance, patients harbouring oncogenic mutations in RAS signalling do not respond to anti-EGFR targeted treatment. Therefore, RAS-independent therapies are needed. Interestingly nilotinib, a clinically approv...
ORGANISM(S): Homo sapiens (Human) 
2018-01-31 | PXD008546 | Pride
Signalling Metastatic colorectal cancer Ddr1 tyrosine kinase 
TranscriptomicsInteractions between Jag1 and Ddr1 in mouse liver
Microarray gene expression experiments to identify differentially expressed genes and pathways in Jag1 conditional/null livers reveal up-regulation of many genes related to fibrosis and ECM interactions. 3 Jag1 conditional/null mutant mice versus 3 littermate wildtype control mice.
ORGANISM(S): Mus musculus 
2014-01-13 | E-GEOD-46577 | biostudies-arrayexpress
ProteomicsSILAC phosphoproteome analysis upon transient Abl1/2 or DDR1 knockdown in human U-2 OS cells
Analysis of changes in the phosphoproteome upon transient siRNA-mediated knockdown of ABL1/ABL2 or DDR1 for 48 hours. CILAC phosphoproteome analysis was conducted after 48hrs using human U-2 OS cells.
ORGANISM(S): Homo sapiens (Human) 
2023-10-24 | PXD023146 | Pride
Abl2 Silac Abl1 Ddr1 
GenomicsDDR1 plays a distinctive role in mammary tumour growth
DDR1 plays a distinctive role in mammary tumour growth
PRJNA578865 | ENA
GenomicsCollagenolysis dependent DDR1 signaling dictates pancreatic cancer outcome
Collagenolysis dependent DDR1 signaling dictates pancreatic cancer outcome
PRJNA849639 | ENA
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