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ProteomicsHighly selective humanized DDR1 mAb reverses immune exclusion by disrupting collagen fiber alignment in breast cancer
Discoidin domain-containing receptor 1 (DDR1) plays an important role in cancer progression. However, the DDR1 function in tumors is still elusive. We recently reported that DDR1 promoted collagen fiber alignment and formation of a physical barrier, which causes immune exclusion from tumors. We also...
ORGANISM(S): Homo sapiens (Human) 
2023-06-19 | PXD042971 | Pride
Ddr1 Breast cancer Prth-101 Hdx-ms Mab 
UnknownA highly selective humanized DDR1 mAb reverses immune exclusion by disrupting collagen fiber alignment in breast cancer.
Not available
S-EPMC10277525 | biostudies-literature
UnknownAB010. A phase 1 trial of PRTH-101, a monoclonal antibody targeting discoidin domain receptor 1 (DDR1), alone or in combination with pembrolizumab, for the treatment of thymic malignancies
Not available
S-EPMC12529548 | biostudies-literature
UnknownAB013. A pivotal phase 2 trial to compare PRTH-101, a monoclonal antibody targeting discoidin domain receptor 1 (DDR1), in combination with an immune checkpoint inhibitor (ICI) and ICI alone, for the treatment of recurrent or metastatic thymic epithelial carcinoma (TEC)
Not available
S-EPMC12529541 | biostudies-literature
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