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GenomicsLRH-1 and PTF1-L coregulate an exocrine pancreas-specific transcriptional network for digestive function [ChIP-Seq]
We have determined the cistrome and transcriptome for the nuclear receptor liver receptor homolog-1 (LRH-1) in the exocrine pancreas. Chromatin immunoprecipitation (ChIP)-seq and RNA-seq analyses reveal that LRH-1 directly induces expression of genes encoding digestive enzymes and secretory and mit...
ORGANISM(S): Mus musculus 
2011-12-09 | E-GEOD-34295 | biostudies-arrayexpress
TranscriptomicsLRH-1 and PTF1-L coregulate an exocrine pancreas-specific transcriptional network for digestive function [RNA-Seq]
Two separate pools of three Flox or two Lrh1t-/- pancreas RNA preparations was subjected to the Illumina RNA-seq protocol. Examination of mRNA levels in induced Lrh1 pancreas knockout and wild-type mice.
ORGANISM(S): Mus musculus 
2011-11-30 | E-GEOD-34030 | biostudies-arrayexpress
ProteomicsPACS1 syndrome variant alters proteomic landscape of developing cortical organoids
Several large-scale genetic studies investigating the cause of neurodevelopmental disorders (NDDs) have been conducted, leading to the identification of hundreds of risk genes. However, our understanding of the mechanisms by which the observed genetic variants act has lagged, limiting translation of...
ORGANISM(S): Homo sapiens (Human) 
2026-08-07 | PXD080130 | Pride
Pacs1 Proteome Neurodevelopmental disorders Brain organoids 
TranscriptomicsPrimary Human Hepatocytes with HCVcc infection timecourse
Goal was to investigate the transcriptional effect of Hepatitis C Virus (HCV) infection upon hepatic gene expression in a primary tissue system. Cultured Primary human hepatocytes were infected with HCV (genotype 2a-JFH1) and maintained through a timecourse in parallel with matched controls of uninf...
ORGANISM(S): Homo sapiens 
2015-01-31 | E-MTAB-2476 | biostudies-arrayexpress
TranscriptomicsInduced Hepatocyte-Like Cells with Interferon timecourse
This experiment investigates the transcriptional effect of Interferon Alpha or Interferon Lambda upon Induced Hepatocyte-Like Cells (iHLCs). Peginterferon lambda-1a (Lambda) is a type III interferon that acts through a unique receptor complex expressed primarily on hepatocytes. In Phase 2b clinical ...
ORGANISM(S): Homo sapiens 
2015-01-31 | E-MTAB-2477 | biostudies-arrayexpress
TranscriptomicsDose response of the BET inhibitor JQ1 in Small-Cell Lung Cancer cell lines.
This is a Dose response experiment carried out using the BET inhibitor JQ1 in SCLC cell lines. Approximately 1x106 cells of cell lines, DMS-53, H69, H1694, H1048, H2227 were treated for 2 hours with a 12 point dose range of JQ1 (7500nM to 0.04nM). Lysates were collected at the end of the treatment ...
ORGANISM(S): Homo sapiens 
2015-05-31 | E-MTAB-3449 | biostudies-arrayexpress
TranscriptomicsA comprehensive assessment of array-based platforms and calling algorithms for detection of copy number variants (WGTP)
Systematic evaluation of eleven array platforms commonly used for CNV detection to address parameters of quality and CNV calling. 18 Samples
ORGANISM(S): Homo sapiens 
2011-06-30 | E-GEOD-28189 | biostudies-arrayexpress
ProteomicsRenal redox proteomic analysis of Memo1-dependent FGF23-driven cell signaling
Memo is a copper-dependent redox enzyme modulating receptor tyrosine kinase signaling by unknown mechanisms (Meira et al., Nat Cell Biol 2004; MacDonald et al., Science Signal 2014). Memo1 deletion causes a phenotype partially resembling Klotho and Fgf23-deficient mice (Haenzi et al., FASEB J 2014; ...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2020-11-04 | MSV000086406 | MassIVE
ProteomicsHs_PFrontalCortex_Silac
Human postmortem frontal cortex proteome
ORGANISM(S): Homo Sapiens (human) 
2012-12-31 | PAe005153 | PeptideAtlas
UnknownIMP dehydrogenase deficiency in Leishmania donovani causes a restrictive growth phenotype in promastigotes but is not essential for infection in mice.
Not available
S-EPMC3202435 | biostudies-literature
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