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MetabolomicsSimultaneously discovering the fate and biochemical effects of pharmaceuticals through untargeted metabolomics
Untargeted metabolomics is an established approach in toxicology for characterising endogenous metabolic responses to xenobiotic exposure. Detecting the xenobiotic and its biotransformation products as part of the metabolomics analysis provides an opportunity to simultaneously gain deep insights int...
2023-07-03 | MTBLS2746 | MetaboLights
ProteomicsRapid and specific degradation of endogenous proteins in mouse models using auxin-inducible degrons
Auxin-inducible degrons are a chemical genetic tool for targeted protein degradation and are widely used to study protein function in cultured mammalian cells. Here, we develop CRISPR-engineered mouse lines that enable rapid and highly specific degradation of tagged endogenous proteins in vivo. Most...
ORGANISM(S): Mus musculus (Mouse) 
2022-06-07 | PXD032374 | Pride
Dia Condensin Auxin degradation 
UnknownBiomarker-Guided Antibiotic Duration for Hospitalized Patients With Suspected Sepsis: The ADAPT-Sepsis Randomized Clinical Trial.
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S-EPMC11862976 | biostudies-literature
UnknownCost-effectiveness of procalcitonin-guided antibiotic duration for hospitalized patients with sepsis.
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S-EPMC12661845 | biostudies-literature
UnknownImpact of postoperative acute kidney injury in patients undergoing major gastrointestinal surgery on 1-year survival and renal outcomes: a national multicentre cohort study.
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S-EPMC8759520 | biostudies-literature
UnknownChallenges of one-year longitudinal follow-up of a prospective, observational cohort study using an anonymised database: recommendations for trainee research collaboratives.
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S-EPMC6909648 | biostudies-literature
UnknownPrognostic model to predict postoperative acute kidney injury in patients undergoing major gastrointestinal surgery based on a national prospective observational cohort study.
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S-EPMC6254006 | biostudies-literature
UnknownCanadian Surgery Forum.
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S-EPMC3432251 | biostudies-literature
UnknownA second update on mapping the human genetic architecture of COVID-19.
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S-EPMC10482689 | biostudies-literature
UnknownValidation of the OAKS prognostic model for acute kidney injury after gastrointestinal surgery.
Not available
S-EPMC8855527 | biostudies-literature
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