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ProteomicsIdentification and quantification of human postmortem frontal cortex proteome with a SILAM mouse brain standard
Prefrontal cortex tissue slices from a cognitively and neurpathologically normal human subject were obtained from the University of Pennsylvania (UPenn) Brain Bank. 300-350 mg grey matter was homogenized in 1.5 ml solution A (0.32 M sucrose, 1mM MgCl2 and 0.1mM CaCl2) with a Teflon pestle. ~100 ?l ...
ORGANISM(S): Homo sapiens (Human) 
2012-12-10 | PXD000004 | Pride
Human Brain Silam Lc-ms/ms 
ProteomicsTargeting the Post-Synaptic Proteome in Alzheimer Disease with Psychosis
Individuals with Alzheimer Disease who develop psychotic symptoms (AD+P) experience more rapid cognitive decline and have reduced indices of synaptic integrity relative to those without psychosis (AD-P). We sought to determine whether the postsynaptic density (PSD) proteome is altered in AD+P relati...
ORGANISM(S): Homo sapiens (Human) 
2023-06-19 | PXD042025 | Pride
Human Brain Alzheimer disease with psychosis 
ProteomicsUncovering diurnal rhythm disruptions of synaptic proteome signaling in prefrontal cortex and nucleus accumbens associated with opioid use disorder
This article presents a study that examines the proteomic alterations associated with opioid use disorder (OUD) in the human brain. The study investigates the interplay between pro-inflammatory signaling, extracellular matrix (ECM) remodeling, and synaptic plasticity in the corticostriatal circuitry...
ORGANISM(S): Homo sapiens (Human) 
2023-10-25 | PXD041333 | Pride
Human Dorsolateral prefrontal cortex Nucleus accumbens Postmortem brain tissue Opiods 
TranscriptomicsTranscription profiling of human monocytic cells THP-1 stimulated with LPS (10ng/ml) in presence or absence of LL-37 (5 ug/ml), as well as with the peptide alone, for 4 hours
The objective of the study was to evaluate transcriptional response of endotoxin-stimulated human monocytic cells in presence or absence of host defense peptide LL-37 at low physiologically relevant concentrations. Human monocytic cells THP-1 were stimulated with LPS (10ng/ml) in presence or absenc...
ORGANISM(S): Homo sapiens 
2006-12-07 | E-FPMI-6 | biostudies-arrayexpress
TranscriptomicsLai-ML-DmD16c3/BS13
modENCODE_submission_3309 This submission comes from a modENCODE project of Eric Lai. For full list of modENCODE projects, see http://www.genome.gov/26524648 Project Goal: We plan to generate a comprehensive catalog of expressed and functional microRNAs, and generate biological evidence for their re...
ORGANISM(S): Drosophila melanogaster 
2012-04-18 | E-GEOD-37434 | biostudies-arrayexpress
GenomicsProgram specificity for Ptf1a in PancreasM-BM- versusM-BM- Neural Tube DevelopmentM-BM- correlates with distinctM-BM- collaborating cofactors and chromatin accessibility
Ptf1a is a lineage-specific basic-helix-loop-helix transcription factor critical in the development of both the pancreas and nervous system. How one transcription factor controls diverse programs of gene expression is a fundamental question in developmental biology. To uncover molecular strategies f...
ORGANISM(S): Mus musculus 
2013-08-15 | E-GEOD-47459 | biostudies-arrayexpress
GenomicsH4K16ac(M).OR Head Nuclei.Solexa
modENCODE_submission_5108 This submission comes from a modENCODE project of Gary Karpen. For full list of modENCODE projects, see http://www.genome.gov/26524648 Project Goal: We aim to determine the locations of the major histone modifications across the Drosophila melanogaster genome. The modificat...
ORGANISM(S): Drosophila melanogaster 
2013-05-28 | E-GEOD-47292 | biostudies-arrayexpress
GenomicsH4K16ac(M).14-16 hr OR embryo.Solexa
modENCODE_submission_4938 This submission comes from a modENCODE project of Gary Karpen. For full list of modENCODE projects, see http://www.genome.gov/26524648 Project Goal: We aim to determine the locations of the major histone modifications across the Drosophila melanogaster genome. The modificat...
ORGANISM(S): Drosophila melanogaster 
2013-05-28 | E-GEOD-47245 | biostudies-arrayexpress
ProteomicsInterplay between nuclear tau phosphorylation and HSV-1 infection.
In this study, we investigated the effects of HSV-1 infection on tau phosphorylation in human brain cortical organoids. Our findings demonstrate that HSV-1 triggers nuclear accumulation of phosphorylated tau in neurons within the developing cortical plate as well as in neural precursor cells (NPCs) ...
ORGANISM(S): Homo sapiens (Human) 
2025-05-06 | PXD047281 | Pride
Human Alzheimers Herpes simplex virus Neurodegenerative diseases Tau 
TranscriptomicsModulation of murine bone marrow derived dendritic cells by IL-4
The archetypal Th2 cytokine interleukin 4 (IL-4) has previously been shown to alternatively activate dendritic cells (DCs) both in vitro and in vivo.To more fully understand the impact of IL-4 dependent alternative activation of DCs, we used mRNA microarrays to define their transcriptional profile. ...
ORGANISM(S): Mus musculus 
2015-04-28 | E-GEOD-59868 | biostudies-arrayexpress
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