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ProteomicsIdentification and quantification of human postmortem frontal cortex proteome with a SILAM mouse brain standard
Prefrontal cortex tissue slices from a cognitively and neurpathologically normal human subject were obtained from the University of Pennsylvania (UPenn) Brain Bank. 300-350 mg grey matter was homogenized in 1.5 ml solution A (0.32 M sucrose, 1mM MgCl2 and 0.1mM CaCl2) with a Teflon pestle. ~100 ?l ...
ORGANISM(S): Homo sapiens (Human) 
2012-12-10 | PXD000004 | Pride
Human Brain Silam Lc-ms/ms 
ProteomicsTargeting the Post-Synaptic Proteome in Alzheimer Disease with Psychosis
Individuals with Alzheimer Disease who develop psychotic symptoms (AD+P) experience more rapid cognitive decline and have reduced indices of synaptic integrity relative to those without psychosis (AD-P). We sought to determine whether the postsynaptic density (PSD) proteome is altered in AD+P relati...
ORGANISM(S): Homo sapiens (Human) 
2023-06-19 | PXD042025 | Pride
Human Brain Alzheimer disease with psychosis 
ProteomicsUncovering diurnal rhythm disruptions of synaptic proteome signaling in prefrontal cortex and nucleus accumbens associated with opioid use disorder
This article presents a study that examines the proteomic alterations associated with opioid use disorder (OUD) in the human brain. The study investigates the interplay between pro-inflammatory signaling, extracellular matrix (ECM) remodeling, and synaptic plasticity in the corticostriatal circuitry...
ORGANISM(S): Homo sapiens (Human) 
2023-10-25 | PXD041333 | Pride
Human Dorsolateral prefrontal cortex Nucleus accumbens Postmortem brain tissue Opiods 
TranscriptomicsTranscription profiling of human monocytic cells THP-1 stimulated with LPS (10ng/ml) in presence or absence of LL-37 (5 ug/ml), as well as with the peptide alone, for 4 hours
The objective of the study was to evaluate transcriptional response of endotoxin-stimulated human monocytic cells in presence or absence of host defense peptide LL-37 at low physiologically relevant concentrations. Human monocytic cells THP-1 were stimulated with LPS (10ng/ml) in presence or absenc...
ORGANISM(S): Homo sapiens 
2006-12-07 | E-FPMI-6 | biostudies-arrayexpress
ProteomicsPACS1 syndrome variant alters proteomic landscape of developing cortical organoids
Several large-scale genetic studies investigating the cause of neurodevelopmental disorders (NDDs) have been conducted, leading to the identification of hundreds of risk genes. However, our understanding of the mechanisms by which the observed genetic variants act has lagged, limiting translation of...
ORGANISM(S): Homo sapiens (Human) 
2026-08-07 | PXD080130 | Pride
Pacs1 Proteome Neurodevelopmental disorders Brain organoids 
TranscriptomicsLai-ML-DmD16c3/BS13
modENCODE_submission_3309 This submission comes from a modENCODE project of Eric Lai. For full list of modENCODE projects, see http://www.genome.gov/26524648 Project Goal: We plan to generate a comprehensive catalog of expressed and functional microRNAs, and generate biological evidence for their re...
ORGANISM(S): Drosophila melanogaster 
2012-04-18 | E-GEOD-37434 | biostudies-arrayexpress
GenomicsProgram specificity for Ptf1a in PancreasM-BM- versusM-BM- Neural Tube DevelopmentM-BM- correlates with distinctM-BM- collaborating cofactors and chromatin accessibility
Ptf1a is a lineage-specific basic-helix-loop-helix transcription factor critical in the development of both the pancreas and nervous system. How one transcription factor controls diverse programs of gene expression is a fundamental question in developmental biology. To uncover molecular strategies f...
ORGANISM(S): Mus musculus 
2013-08-15 | E-GEOD-47459 | biostudies-arrayexpress
GenomicsH4K16ac(M).OR Head Nuclei.Solexa
modENCODE_submission_5108 This submission comes from a modENCODE project of Gary Karpen. For full list of modENCODE projects, see http://www.genome.gov/26524648 Project Goal: We aim to determine the locations of the major histone modifications across the Drosophila melanogaster genome. The modificat...
ORGANISM(S): Drosophila melanogaster 
2013-05-28 | E-GEOD-47292 | biostudies-arrayexpress
GenomicsH4K16ac(M).14-16 hr OR embryo.Solexa
modENCODE_submission_4938 This submission comes from a modENCODE project of Gary Karpen. For full list of modENCODE projects, see http://www.genome.gov/26524648 Project Goal: We aim to determine the locations of the major histone modifications across the Drosophila melanogaster genome. The modificat...
ORGANISM(S): Drosophila melanogaster 
2013-05-28 | E-GEOD-47245 | biostudies-arrayexpress
ProteomicsInterplay between nuclear tau phosphorylation and HSV-1 infection.
In this study, we investigated the effects of HSV-1 infection on tau phosphorylation in human brain cortical organoids. Our findings demonstrate that HSV-1 triggers nuclear accumulation of phosphorylated tau in neurons within the developing cortical plate as well as in neural precursor cells (NPCs) ...
ORGANISM(S): Homo sapiens (Human) 
2025-05-06 | PXD047281 | Pride
Human Alzheimers Herpes simplex virus Neurodegenerative diseases Tau 
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