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ProteomicsIdentification and quantification of human postmortem frontal cortex proteome with a SILAM mouse brain standard
Prefrontal cortex tissue slices from a cognitively and neurpathologically normal human subject were obtained from the University of Pennsylvania (UPenn) Brain Bank. 300-350 mg grey matter was homogenized in 1.5 ml solution A (0.32 M sucrose, 1mM MgCl2 and 0.1mM CaCl2) with a Teflon pestle. ~100 ?l ...
ORGANISM(S): Homo sapiens (Human) 
2012-12-10 | PXD000004 | Pride
Human Brain Silam Lc-ms/ms 
ProteomicsTargeting the Post-Synaptic Proteome in Alzheimer Disease with Psychosis
Individuals with Alzheimer Disease who develop psychotic symptoms (AD+P) experience more rapid cognitive decline and have reduced indices of synaptic integrity relative to those without psychosis (AD-P). We sought to determine whether the postsynaptic density (PSD) proteome is altered in AD+P relati...
ORGANISM(S): Homo sapiens (Human) 
2023-06-19 | PXD042025 | Pride
Human Brain Alzheimer disease with psychosis 
ProteomicsUncovering diurnal rhythm disruptions of synaptic proteome signaling in prefrontal cortex and nucleus accumbens associated with opioid use disorder
This article presents a study that examines the proteomic alterations associated with opioid use disorder (OUD) in the human brain. The study investigates the interplay between pro-inflammatory signaling, extracellular matrix (ECM) remodeling, and synaptic plasticity in the corticostriatal circuitry...
ORGANISM(S): Homo sapiens (Human) 
2023-10-25 | PXD041333 | Pride
Human Dorsolateral prefrontal cortex Nucleus accumbens Postmortem brain tissue Opiods 
ProteomicsTargeting the Post-Synaptic Proteome in Alzheimer Disease with Psychosis
Individuals with Alzheimer Disease with psychotic symptoms (AD+P) experience more rapid cognitive and functional decline, and have reduced indices of synaptic integrity, relative to those without psychosis (AD-P). We hypothesized the postsynaptic density (PSD) proteome is altered in AD+P relative to...
ORGANISM(S): Homo sapiens (Human) 
2023-06-19 | PXD042026 | Pride
Alzheimer’s disease  psychosis  post-synaptic density  proteomics: systems pharmacology 
ProteomicsInterplay between nuclear tau phosphorylation and HSV-1 infection.
In this study, we investigated the effects of HSV-1 infection on tau phosphorylation in human brain cortical organoids. Our findings demonstrate that HSV-1 triggers nuclear accumulation of phosphorylated tau in neurons within the developing cortical plate as well as in neural precursor cells (NPCs) ...
ORGANISM(S): Homo sapiens (Human) 
2025-05-06 | PXD047281 | Pride
Human Alzheimers Herpes simplex virus Neurodegenerative diseases Tau 
ProteomicsHs_PFrontalCortex_Silac
Human postmortem frontal cortex proteome
ORGANISM(S): Homo Sapiens (human) 
2012-12-31 | PAe005153 | PeptideAtlas
ProteomicsAge-related loss of large dendritic spines in the precuneus is statistically mediated by proteins which are predicted targets of existing drugs
Preservation of dendritic spines is a putative mechanism of protection against cognitive impairment despite development of Alzheimer Disease (AD)-related pathologies. Aging, the chief late-onset AD risk factor, is associated with dendritic spine loss in select brain areas. However, no study to our k...
ORGANISM(S): Homo sapiens (Human) 
2026-08-07 | PXD057115 | Pride
Proteomics Human Brain tissue Alzheimer disease Dendritic spines 
TranscriptomicsTranscription profiling of mouse pre-implantation development over twelve time points from the germinal vesicle (GV) stage oocyte to the late (expanded) blastocyst
The goal of the experiments was to profile and analyze gene activity during murine pre-implantation development. Samples were collected at twelve time points from the germinal vesicle (GV) stage oocyte to the late (expanded) blastocyst.
ORGANISM(S): Mus musculus 
2004-02-19 | E-MEXP-51 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by array of Candida albicans populations exposed to a temperature shift from 25 degrees to 37 degrees
Seperate White and Opaque Candida albicans populations were exposed to a temperature shift from 25 degrees to 37 degrees. Samples were then harvested at various time points to follow the effects of the shift on the two cell types, particularly the opaque cell type which switches to the white cell ...
ORGANISM(S): Candida albicans 
2011-05-08 | E-MEXP-2705 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by array of C. albicans to identify the commintment point of the temperature induced opaque-to-white switch
This experiment is a characterization of the commitment point of the temperature induced opaque-to-white switch in the fungal pathogen Candida albicans. This experiment examines changes in the transcriptome occurring at the 50% commitment points for both the wild type and WOR1/wor1 strains in order...
ORGANISM(S): Candida albicans 
2011-07-07 | E-MEXP-2834 | biostudies-arrayexpress
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