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Metabolomics13C glucose labelling studies using 2D NMR is a useful tool for determining ex vivo whole organ metabolism during hypothermic machine perfusion of kidneys
Background: The aim of this study is to determine the feasibility of using Nuclear Magnetic Resonance (NMR) tracer studies (13C-enriched glucose) to detect ex vivo de novo metabolism in the perfusion fluid and cortical tissue of porcine kidneys during hypothermic machine perfusion (HMP). Methods: Po...
2017-10-16 | MTBLS367 | MetaboLights
MetabolomicsMetabolic profiling during ex vivo machine perfusion of the human liver (part III)
Not available
ORGANISM(S): Homo sapiens 
ST000413 | MetabolomicsWorkbench
MetabolomicsMetabolic profiling during ex vivo machine perfusion of the human liver (part I)
Not available
ORGANISM(S): Homo sapiens 
ST000412 | MetabolomicsWorkbench
ProteomicsTherapeutic hyperthermia promotes lipid export and HSP70/90 during machine perfusion of human livers
Liver transplantation is the only curative option for end-stage liver disease. Donor shortages necessitate the use of higher risk donor livers, including fatty livers, which are more susceptible to ischemia reperfusion injury. Machine perfusion has improved graft utilization and is typically perform...
ORGANISM(S): Homo sapiens (Human) 
2025-05-26 | PXD056736 | Pride
Proteomics Transplant Hyperthermia Liver Machine perfusion 
ProteomicsDoxycycline alters porcine renal proteome and degradome during hypothermic machine perfusion
Ischemia/reperfusion injury (IRI) is a hallmark of tissue injury in donation after circulatory death (DCD) kidneys. The implementation of hypothermic machine perfusion (HMP) provides a platform for repair of DCD kidneys. Doxycycline administration has shown protective effects during IRI. Here, we ex...
ORGANISM(S): Sus scrofa domesticus (domestic pig) 
2022-08-12 | PXD029599 | Pride
Renal transplantation  ischemia/reperfusion injury  machine perfusion  proteomics 
ProteomicsProteomic profiling during normothermic perfusion predicts liver graft quality and outcomes after transplantation
This study investigates the proteomic dynamics of human liver grafts during normothermic machine perfusion (NMP), using mass spectrometry-based analysis. A total of 16 donor livers were perfused with NMP and sampled at three distinct time points to assess molecular changes and their association with...
ORGANISM(S): Homo sapiens (Human) 
2026-04-27 | PXD067270 | Pride
Quantitative proteomics Graft viability Normothermic machine perfusion Biliary complications Liver transplantation 
GenomicsGene expression profiling of human livers during normothermic machine perfusion
Gene expression profiling of human livers during normothermic machine perfusion
PRJNA1098409 | ENA
GenomicsTranscriptomic analysis of Kidney Machine normothermic perfusion and comparision to cold storage
Transcriptomic analysis of Kidney Machine normothermic perfusion and comparision to cold storage
PRJNA497370 | ENA
ProteomicsTISSUE AND URINARY PROTEOMIC ANALYSIS OF KIDNEYS UNDERGOING SHORT PERIOD OF NORMOTHERMIC MACHINE PERFUSION.
To identify the main biological effects of the normothermic machine perfusion (NMP) in marginal kidneys, we measured, by mass spectrometry analysis, changes in the proteomic profile of kidney tissues and urines of eight organs reconditioned for 120 minutes (by a Kidney Assist device). Biopsy specime...
ORGANISM(S): Homo sapiens (Human) 
2023-05-10 | PXD036432 | Pride
Normothermic machine perfusion Proteomics Mass spectrometry Urines Kidney 
GenomicsPan-caspase inhibition during normothermic machine perfusion of discarded livers mitigates ischemia-reperfusion injury
Pan-caspase inhibition during normothermic machine perfusion of discarded livers mitigates ischemia-reperfusion injury
PRJNA836578 | ENA
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