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ProteomicsαB-crystallin elastin-like polypeptides for sustained ocular drug delivery
The unfolded protein response (UPR) has been mechanistically implicated in multiple ocular disorders, including age-related macular degeneration (AMD). Therapeutic intervention using an αB-crystallin-derived ‘mini-cry’ chaperone peptide has potential to restore proteostasis; however, its low molecul...
ORGANISM(S): Homo sapiens (Human) 
2026-10-19 | PXD081775 | Pride
Microscopy Proteomics Er stress Elps Apoptosis Fibril 
TranscriptomicsTranscription profiling by array of breast cancer cell lines and correlations with fibroblast growth factor receptor (FGFR) signalling and repression
Baseline gene expression profiling of breast cancer cell lines and correlations with FGFR signalling and repression
ORGANISM(S): Homo sapiens 
2011-12-01 | E-MTAB-879 | biostudies-arrayexpress
GenomicA Pharmcogenetic Study of Bipolar Disorder in a Taiwanese Han Chinese Population (TWBP)

Objective: To identify genetic variants associated with response to lithium prophylaxis treatment.

Materials: 294 bipolar I (BPI) patients receiving lithium treatment, a subset of 1761 bipolar I (BPI) patients recruited by the Taiwan Bipolar Consortium. Lithium response was assessed based ...

phs000692 | dbGaP
TranscriptomicsProfiling of SF188 ATRX isogenic glioma cells
Methylation profiling of SF188 paediatric high grade glioma cell line isogenic clones carrying CRISR/Cas9 frameshift deletions in ATRX
ORGANISM(S): Homo sapiens 
2019-06-01 | E-MTAB-7800 | biostudies-arrayexpress
UnknownMass spectrometry imaging for dissecting steroid intracrinology within target tissues.
Not available
S-EPMC4392804 | biostudies-literature
TranscriptomicsIllumina Infinium HumanMethylation450 BeadChip profiling of paediatric high grade gliomas and diffuse intrinsic pontine gliomas
We have used Illumina Infinium HumanMethylation450 BeadChip array profiling to profile paediatric high grade gliomas and diffuse intrinsic pontine gliomas. The 450K methylation array is being used to separate brain tumour samples on the basis of their methylation profiles which represent the cell of...
ORGANISM(S): Homo sapiens 
2017-09-28 | E-MTAB-5528 | biostudies-arrayexpress
ProteomicsThe Bloom’s syndrome helicase BLM functions as a homodimer within the Bloom’s complex
Homologous recombination (HR) is an essential and highly regulated cellular process. Unintended HR in somatic cells is potentially deleterious; it can result in translocations and/or somatic cell loss of heterozygosity. This is suppressed by the BLM protein in combination with topoisomerase III, RM...
ORGANISM(S): Homo sapiens (Human) 
2022-01-17 | PXD011078 | Pride
Blm Crosslinking ms Structural proteomics Bloom’s syndrome 
TranscriptomicsInfant high grade gliomas comprise multiple subgroups characterised by novel targetable gene fusions and better survival
Methylation array profiling of infant high grade gliomas identifies an intrinsic group of tumours with epigenetic profiles distinct from gliomas in older children. These tumours are characterised by very few recurrent mutations and carry a very high frequency of fusion genes. They can be diagnosed a...
ORGANISM(S): Homo sapiens 
2019-08-12 | E-MTAB-7804 | biostudies-arrayexpress
TranscriptomicsInfant high grade gliomas comprise multiple subgroups characterised by novel targetable gene fusions and better survival
Methylation array profiling of infant high grade gliomas identifies an intrinsic group of tumours with epigenetic profiles distinct from gliomas in older children. These tumours are characterised by very few recurrent mutations and carry a very high frequency of fusion genes. They can be diagnosed a...
ORGANISM(S): Homo sapiens 
2019-08-09 | E-MTAB-7802 | biostudies-arrayexpress
UnknownLocalisation of corticosteroids in male mouse kidney by mass spectrometry imaging.
Not available
S-EPMC12927002 | biostudies-literature
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