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ProteomicsA Targeted in Vivo SILAC Approach for Quantification of Drug Metabolism Enzymes: Regulation by the Constitutive Androstane Receptor
The modulation of drug metabolism enzyme (DME) expression by therapeutic agents is a central mechanism of drug–drug interaction and should be assessed as early as possible in preclinical drug development. Direct measurement of DME levels is typically achieved by Western blotting, qPCR, or microarray...
ORGANISM(S): Mus musculus (Mouse) 
2014-02-14 | PXD000675 | Pride
Drug metabolism  drug−drug interaction  constitutive androstane receptor  protein quantification  targeted in vivo silac 
ProteomicsAn Enhanced in vivo SILAC model for Quantification of Drug Metabolism Enzymes
Many of the enzymes involved in xenobiotic metabolism are maintained at a low basal level and are only synthesized in response to activation of upstream sensor/effector proteins. This induction can have implications in a variety of contexts, particularly during the study of the pharmacokinetics, pha...
ORGANISM(S): Mus musculus (Mouse) 
2015-01-09 | PXD001210 | Pride
In vivo silac Pharmacology Drug-drug interaction Xenobiotic metabolism Drug metabolism Toxicology Cytochrome p450 
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