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The mono-ADP-ribosylhydrolase MacroD1 has recently been described to exclusively localize to mitochondria. However, to what extent and how MacroD1 controls metabolic homeostasis remains poorly understood. Here, we identify MacroD1 as a mitochondrial regulator of carbohydrate metabolism. Loss of Macr...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2025-05-16 | PXD020281 | Pride
Effect of MacroD1 knockout on gene expression of heart on mouse septic model
Sepsis-Induced Myocardial Injury (SIMI) is a severe form of cardiac dysfunction that involves multiple mechanisms, including inflammatory damage and mitochondrial injury . Our research has demonstrated that MacroD1 plays a significant role in SIMI. By employing liquid chromatography-mass spectrometr...
ORGANISM(S): Mus <genus> 
2024-12-19 | PXD059021 |
Metabolic plasticity of tissues determines the degree and reversibility of organ damage under inflammatory challenges. While treating septic cardiomyopathy (SCM) with high mortality, metabolic management should be considered. Still, similar pan-organ metabolic anomalies usually yield contrasting res...
ORGANISM(S): Mus musculus 
2025-06-18 | GSE253829 | GEO
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