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ProteomicsComprehensive ADP-ribosylome analysis identifies tyrosine as an ADP-ribose acceptor site
Despite recent mass spectrometry (MS)-based breakthroughs, comprehensive ADP-ribose (ADPr)-site identification and localization remain challenging. Here, we report the establishment of an unbiased, multistep ADP-ribosylome data analysis workflow that led to the identification of tyrosine as a novel ...
ORGANISM(S): Homo sapiens (Human) 
2018-06-28 | PXD009948 | Pride
Tyrosine adp-ribosylation Parp1 Artd1 Hpf1 Rsp3a Genotoxic stress Adp-ribosylation 
ProteomicsOxidative stress induced ADP-ribosylome
Oxidative stress is a potent inducer of protein ADP-ribosylation. Although the proteins modified under oxidative stress have been identified, it is not clear, whether the number of modified proteins and/or the number ADP-ribosylation sites varies with stress intensity. Here, we investigated both the...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2016-11-13 | MSV000080334 | MassIVE
UnknownComprehensive ADP-ribosylome analysis identifies tyrosine as an ADP-ribose acceptor site.
Not available
S-EPMC6073207 | biostudies-literature
ProteomicsThe regulatory landscape of the human HPF1- and ARH3-dependent ADP-ribosylome (part 1)
Despite the involvement of Poly(ADP-ribose) polymerase-1 (PARP1) in many important biological pathways, the target residues of PARP1-mediated ADP-ribosylation remain ambiguous. To explicate the ADP-ribosylation regulome, we analyze human cells depleted for key regulators of PARP1 activity, histone P...
ORGANISM(S): Homo sapiens (Human) 
2021-10-07 | PXD023835 | Pride
Parp1 Adpr Hpf1 Arh3 Par Parg Af1521 Mar Adp-ribosylation 
ProteomicsThe regulatory landscape of the human HPF1- and ARH3-dependent ADP-ribosylome (part 2)
Despite the involvement of Poly(ADP-ribose) polymerase-1 (PARP1) in many important biological pathways, the target residues of PARP1-mediated ADP-ribosylation remain ambiguous. To explicate the ADP-ribosylation regulome, we analyze human cells depleted for key regulators of PARP1 activity, histone P...
ORGANISM(S): Bos taurus (Bovine) Homo sapiens (Human) 
2021-10-11 | PXD027504 | Pride
Parp1 Adpr Hpf1 Arh3 Par Parg Af1521 Mar Adp-ribosylation 
UnknownThe regulatory landscape of the human HPF1- and ARH3-dependent ADP-ribosylome.
Not available
S-EPMC8501107 | biostudies-literature
UnknownIdentification of the Mouse T Cell ADP-Ribosylome Uncovers ARTC2.2 Mediated Regulation of CD73 by ADP-Ribosylation.
Not available
S-EPMC8421852 | biostudies-literature
ProteomicsA site-specific analysis of the ADP-Ribosylome unveils Homogeneous Serine ADP-Ribosylation across wild-type and BRCA-mutant Breast Cancer cell lines
ADP-ribosylation (ADPr) signaling plays a crucial role in the DNA damage response. Inhibitors against the main enzyme catalyzing ADPr after DNA damage – PARP1 – are used as targeted therapies against breast cancers with BRCA1/2 mutations. However, development of resistance to PARP inhibitors (PARPi)...
ORGANISM(S): Homo sapiens (Human) 
2024-08-02 | PXD047613 | Pride
Proteomics Mass spectrometry Ethcd Parp inhibitor sensitivity Parp Af1521 macrodomain Adp-ribosylome Parg Adp-ribosylation 
UnknownThe RiboMaP Spectral Annotation Method Applied to Various ADP-Ribosylome Studies Including INF-γ-Stimulated Human Cells and Mouse Tissues.
Not available
S-EPMC8996112 | biostudies-literature
ProteomicsMitochondrial ADP-ribosylation regulates NAD+-dependent genotoxic stress responses
ADP-ribosylome analysis in human U20S cells and mouse muscle tissues
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2021-09-08 | PXD013918 | Pride
Mitochondria U2os Adp-ribosylation Muscle 
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