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ProteomicsRNAmetasome, a multi-protein complex for the macromolecule biogenesis in human cells
The RNAmetasome, a multi-protein complex for the macromolecule biogenesis in human cells, is defined and characterized.
ORGANISM(S): Homo sapiens (Human) 
2021-12-10 | PXD024234 | Pride
Macromolecule biogenesis Metasome 
UnknownRNAmetasome network for macromolecule biogenesis in human cells.
Not available
S-EPMC8674265 | biostudies-literature
TranscriptomicsRe-evaluation of the roles of DROSHA, Exportin 5, and DICER in microRNA biogenesis
Biogenesis of canonical microRNAs (miRNAs) involves multiple steps: nuclear processing of primary miRNA (pri-miRNA) by DROSHA, nuclear export of precursor miRNA (pre-miRNA) by Exportin 5 (XPO5), and cytoplasmic processing of pre-miRNA by DICER. To gain a deeper understanding of the contribution of e...
ORGANISM(S): Homo sapiens 
2016-03-17 | E-GEOD-77989 | biostudies-arrayexpress
TranscriptomicsComplexity of Murine Cardiomyocyte miRNA Biogenesis, Sequence Variant Expression and Function
microRNAs (miRNAs) are critical to heart development and disease. Emerging research indicates that regulated precursor processing can give rise to an unexpected diversity of miRNA variants. We subjected small RNA from murine HL-1 cardiomyocyte cells to next generation sequencing to investigate the r...
ORGANISM(S): Mus musculus 
2012-07-20 | E-GEOD-39531 | biostudies-arrayexpress
TranscriptomicsRunx1 deficiency decreases ribosome biogenesis and confers stress resistance to hematopoietic stem and progenitor cells
The transcription factor RUNX1 is frequently mutated in myelodysplastic syndrome and leukemia. RUNX1 mutations can be early events, creating pre-leukemic stem cells that expand in the bone marrow. Here we show that, counter-intuitively, Runx1 deficient hematopoietic stem and progenitor cells (HSPCs)...
ORGANISM(S): Mus musculus 
2015-07-27 | E-GEOD-67609 | biostudies-arrayexpress
TranscriptomicsSch9 regulates ribosome biogenesis via Stb3, Dot6 and Tod6 and the histone deacetylase complex RPD3L (mRNA-Seq data)
TORC1 is a structurally and functionally conserved multiprotein complex that regulates many aspects of eukaryote growth including the synthesis and assembly of ribosomes. The protein kinase activity of this complex is responsive to environmental cues and is potently inhibited by the natural product ...
ORGANISM(S): Saccharomyces cerevisiae 
2011-07-01 | E-GEOD-29122 | biostudies-arrayexpress
TranscriptomicsRoles of RDR701 and DCLs in Rice PhasiRNA biogenesis
In this study, we analyzed function of the rice RDR701 and various DCLs proteins in small RNA processing. small RNA deep sequencing analyses revealed that RDR701 and OsDCL4 is involved in tasiRNAs and 21- and 24-nt phasiRNAs biogenesis. Further analyses indicate RDR701 coupling with OsDCL4 and OsDCL...
ORGANISM(S): Oryza sativa 
2012-07-02 | E-GEOD-26405 | biostudies-arrayexpress
TranscriptomicsAnalysis of intron sequences reveals hallmarks of circular RNA biogenesis in animals
Circular RNAs (circRNAs) are a large class of animal RNAs. To investigate possible circRNA functions, it is important to understand circRNA biogenesis. Besides human Alu repeats, sequence features that promote exon circularization are largely unknown. We experimentally identified new circRNAs in C. ...
ORGANISM(S): Caenorhabditis elegans 
2015-01-06 | E-GEOD-63823 | biostudies-arrayexpress
TranscriptomicsRole of σ54 in the regulation of genes involved in biogenesis of type I and type IV pili in Xylella fastidiosa
The phytopathogen Xylella fastidiosa produces two classes of pili, long type IV pili and short type I pili, which are involved in motility and adhesion. In this work, we have investigated the role of σ54 factor and its involvement in the regulation of fimbrial biogenesis in X. fastidiosa. An rpoN n...
ORGANISM(S): Xylella fastidiosa 
2010-06-25 | E-GEOD-8097 | biostudies-arrayexpress
TranscriptomicsMicroRNA-Directed siRNA Biogenesis in Caenorhabditis elegans
C.elegans small RNAs from HA::ALG-1, HA::ALG-2 and HA::RDE-1 IP and rde-1 mutants Small RNAs were cloned from transgenic or mutant C. elegans adults. Sequencing was performed using 454 and Illumina platforms.
ORGANISM(S): Caenorhabditis elegans 
2010-04-14 | E-GEOD-20649 | biostudies-arrayexpress
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