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ProteomicsPrecision N-glycoproteomics of murine peritoneal macrophage
In this study, we profiled the precision N-glycoproteome of the murine peritoneal macrophage under different stimulation.
ORGANISM(S): Mus musculus (Mouse) 
2021-06-12 | PXD026629 | Pride
Inflammation Glycoproteomics Macrophage 
ProteomicsIdentification of novel glycoproteins expressed on human macrophage surface using glycoproteomics
Prostate cancer is a leading cause of cancer-related deaths of men in the U.S. While localized disease is highly treatable by surgical resection and radiation, cancer that has metastasized remains incurable. Immune cells that primarily scavenge debris, promote prostate cancer angiogenesis and woun...
ORGANISM(S): Homo sapiens (Human) 
2017-03-31 | PXD005080 | Pride
Macrophage glycoproteome Glycoproteomics Prostate cancer Human 
ProteomicsDeciphering the mechanisms of macrophage polarization through comprehensive analysis of protein glycosylation in cells and on the surface
In this work, we conducted an in-depth characterization of protein glycosylation including total glycoproteins and surface ones across different macrophage phenotypes using mass spectrometry (MS)-based proteomics. The global analysis of glycoproteins was performed using the boronic acid-conjugated d...
ORGANISM(S): Homo sapiens (Human) 
2024-08-08 | PXD053647 | Pride
Glycoproteomics Proteomics Tumor-associated macrophages M1 macrophage M2 macrophage Surfaceome Macrophage polarization 
UnknownMonitoring Cell-surface N-Glycoproteome Dynamics by Quantitative Proteomics Reveals Mechanistic Insights into Macrophage Differentiation.
Not available
S-EPMC5417820 | biostudies-literature
UnknownInvestigating Patterns of Immune Interaction in Ovarian Cancer: Probing the O-glycoproteome by the Macrophage Galactose-Like C-type Lectin (MGL).
Not available
S-EPMC7600217 | biostudies-literature
ProteomicsMycobacterium tuberculosis Infection Manipulates the Glycosylation Machinery and the N-Glycoproteome of Human Macrophages and their Microparticles
Tuberculosis (TB) remains a prevalent and lethal infectious disease. The glycobiology associated with Mycobacterium tuberculosis infection of frontline alveolar macrophages is still unresolved. Herein, we investigated the regulation of protein N-glycosylation in human macrophages and their secreted ...
ORGANISM(S): Homo sapiens (Human) 
2024-01-26 | PXD005169 | Pride
Macrophage Proteomics Mycobacterium tuberculosis Tuberculosis Glycoprofiling Microparticle N-glycosylation Exoglycosidase Glycomics Glycoproteome Lc-ms/ms 
ProteomicsSite-specific N-glycoproteomic analysis of four M2 macrophage subtypes derived from human THP-1 cells
In this study, we performed site-specific N-glycoproteomic analysis of THP-1 derived four M2 macrophage subtypes (M2a, M2b, M2c, and M2d) by StrucGP method combined with 2D-LC-MS/MS analysis, and revealed the distribution regularities and characters of N-glycans.
ORGANISM(S): Homo sapiens (Human) 
2025-12-23 | PXD048964 | Pride
Glycoproteome M2 subtypes Macrophage 
ProteomicsCell surface mapping and monitoring of cell surface dynamics
Here, we present a simple and robust N-linked glycoproteome enrichment protocol optimized for deep coverage of the plasma membrane proteome. The procedure was applied to characterize the cell surface proteome of 15 standard laboratory human cell lines and three primary cell types. We observed signif...
ORGANISM(S): Homo sapiens (Human) 
2017-03-27 | PXD005846 | Pride
Cell surface Primary cells N-linked glycoproteomics 
ProteomicsProbing the ovarian cancer O-glycoproteome by the Macrophage Galactose like C-type Lectin (MGL): dissecting novel patterns of immune recognition
Glycosylation, the posttranslational linking of sugar molecules to proteins, is notoriously altered during tumor transformation. More specifically in carcinomas, GalNAc-type O-glycosylation, is characterized by biosynthetically immature truncated glycans present on the cancer cell surface which prof...
ORGANISM(S): Homo sapiens (Human) 
2020-10-19 | PXD017510 | Pride
Ovarian cancer O-glycosylation Cancer immunotherapy Tn antigen Dcs Tumor biomarker 
ProteomicsDeciphering the Mechanisms of Macrophage Polarization through Comprehensive Analysis of Protein Glycosylation in Cells and on the Cell Surface
Targeting tumor-associated macrophages (TAMs) holds great promise for cancer immunotherapy. Surface glycoproteins in macrophages regulate their interactions with tumor cells and represent emerging therapeutic targets. Given the crucial roles of protein glycosylation in immune function and cancer, we...
ORGANISM(S): Homo sapiens (Human) 
2026-08-22 | PXD071681 | Pride
Primary human macrophages  lc-ms-based proteomics  cell surface proteins  glycosylation 
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