Macular degeneration

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Unknown (4995)
Transcriptomics (464)
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Proteomics (69)
Metabolomics (17)
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Genomic (7)
Methylation profiling (6)
Clinical (1)

Organisms

Homo sapiens (245)
Mus musculus (159)
Rattus norvegicus (14)
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synthetic construct (5)
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Acinetobacter baumannii 34654 (1)
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Acinetobacter baumannii 1207552 (1)
Acinetobacter baumannii 1428368 (1)
uncultured marine microorganism (1)
Pseudomonas syringae pv. syringae B728a (1)
Ampelisca abdita (1)
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Heterobasidion irregulare (1)

Organisms

Homo sapiens (160)
Mus musculus (105)
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unidentified (3)
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human nasopharyngeal metagenome (1)
Vaccinium corymbosum (1)
human eye metagenome (1)
Oryctolagus cuniculus (1)
human feces metagenome (1)
Canis lupus familiaris (1)
Caenorhabditis elegans (1)
human gut metagenome (1)

Repository

ENA (343)
geo (262)
biostudies-arrayexpress (242)
pride (48)
EGA (25)
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jPOST (1)
MetabolomicsWorkbench (1)
PeptideAtlas (1)

Tissue

Retina (11)
Cell culture (9)
Epithelial cell (5)
Retinal pigment epithelial cell (5)
Blood plasma (4)
Eye (4)
Vitreous humor (4)
Choroid (3)
Retinal pigment epithelium cell (3)
Anterior chamber of the eye (2)
Conjunctiva (2)
Cornea (2)
Iris (2)
Retinal pigment epithelium (2)
Sclera (2)
Tear (2)
Blood (1)
Eye (1)
Blood cell (1)
Choroidal cell of the eye (1)
Embryonic stem cell (1)
Endothelial cell (1)
Kidney (1)
Microglial cell (1)
Monocyte (1)
Neural retina (1)
Pericyte cell (1)
Pluripotent stem cell (1)
Primary cell (1)
R1 photoreceptor cell (1)

Disease

Age related macular degeneration (17)
Disease free (2)
High bone mineral density (1)
Multibacillary (1)
Diminished Ovarian Reserve (DOR) (1)
Normal (1)
Parkinson Disease (1)
Not Available (1)
Eye disease (1)
Age related macular degeneration 1 (1)
Degeneration of macula and posterior pole (1)
Diabetic retinopathy (1)
Epiretinal membrane (1)
Macular degeneration (1)
Proliferative diabetic retinopathy (1)

Technology Type

Mass Spectrometry (48)
Shotgun proteomics (28)
Mass spectrometry (8)
Bottom-up proteomics (8)
Mass spectrometry assay (6)
Data-independent acquisition (6)
Data-dependent acquisition (4)
SWATH MS (3)
Illumina HiSeq 2500 (ILLUMINA) (2)
Illumina (2)
Affinity purification coupled with mass spectrometry proteomics (2)
Gel-based experiment (2)
Genome-Wide Human SNP Array 6.0 - Thermo Fisher Scientific (1)
HiSeq X Ten, ILLUMINA (1)
NMR (1)
HDMSE (1)
SRM/MRM (1)

Instrument Platform

Illumina NovaSeq 6000 (18)
LTQ Orbitrap Elite (6)
Liquid Chromatography MS - negative - hilic (5)
Flow Cytometer (4)
BGISEQ-500 (4)
Illumina HiSeq 4000 (4)
Liquid Chromatography MS - negative - reverse-phase (4)
NA (3)
Illumina HiSeq 2500 (3)
NextSeq 500 (3)
Thermomixer (2)
IScan (2)
Illumina HiSeq 2000 (2)
Orbitrap Exploris 480 (2)
LTQ (2)
Real-time PCR Thermal Cycler (1)
Flow cytometer (1)
Illumina NovaSeq X (1)
N/a (1)
NextSeq 2000 (1)
NextSeq 550 (1)
- (1)
TripleTOF 5600+|1002584 (1)
Instrument (1)
LTQ Orbitrap (1)
OrbiTrap Exactive Q HF (1)
Orbitrap Eclipse (1)
Orbitrap Fusion Lumos (1)
Q Exactive HF (1)
Q Exactive HF-X (1)

Publication Date

2026 (75)
2022 (51)
2025 (48)
2024 (42)
2023 (37)
2012 (35)
2010 (32)
2014 (31)
2015 (28)
2011 (28)
2021 (26)
2013 (26)
2020 (24)
2019 (21)
2018 (20)
2016 (19)
2017 (13)
2009 (12)
2008 (8)
2007 (6)
2006 (5)
2005 (1)
2004 (1)

UNIPROT ID/AC

A0A024R8H9 (1)
A0A024RC46 (1)
A0A075B6P5 (1)
A0A087WT59 (1)
A0A087WTX5 (1)
A0A087WVW2 (1)
A0A087WVZ5 (1)
A0A087WWK8 (1)
A0A087WXI0 (1)
A0A087WYL9 (1)
A0A087X130 (1)
A0A087X1S3 (1)
A0A087X1V9 (1)
A0A0A0MS07 (1)
A0A0A0MS51 (1)
A0A0B4J1V0 (1)
A0A0B4J220 (1)
A0A0C4DG89 (1)
A0A0C4DGT3 (1)
A0AVT1 (1)
A0FGR8 (1)
A0FGR8-2 (1)
A0FGR8-6 (1)
A0M8Q6 (1)
A0N5G5 (1)
A0PJW6 (1)
A1L0T0 (1)
A2BFH1 (1)
A2IPH7 (1)
A2IPI2 (1)

ENSEMBL ID

ENSG00000170477 (1)

CHEBI ID

CHEBI:73134 (6)
CHEBI:17203 (6)
CHEBI:16737 (6)
CHEBI:17596 (6)
CHEBI:28319 (5)
CHEBI:16708 (5)
CHEBI:506227 (5)
CHEBI:16349 (5)
CHEBI:28044 (5)
CHEBI:17012 (5)
CHEBI:17385 (5)
CHEBI:17310 (5)
CHEBI:17509 (5)
CHEBI:18050 (5)
CHEBI:15727 (5)
CHEBI:17568 (5)
CHEBI:7916 (5)
CHEBI:16015 (5)
CHEBI:16750 (5)
CHEBI:15763 (5)
CHEBI:17154 (5)
CHEBI:16347 (5)
CHEBI:17895 (5)
CHEBI:28865 (5)
CHEBI:17351 (5)
CHEBI:17368 (5)
CHEBI:52330 (4)
CHEBI:74797 (4)
CHEBI:75011 (4)
CHEBI:18024 (4)

Metabolite Name

Cytosine (7)
Creatinine (7)
Cyclohexylamine (6)
Uracil (6)
Betaine (6)
L-Proline (6)
Linoleic acid (6)
Adenine (6)
L-Tyrosine (6)
1-Palmitoyl-2-hydroxy-sn-glycero-3-phosphoethanolamine (5)
Lumichrome (5)
Pantothenate (5)
L-Histidine (5)
Indole (5)
N-Acetylneuraminic acid (5)
L-Lysine (5)
Oleic acid (5)
L-Glutamine (5)
L-Glutamate (5)
Xanthine (5)
Glycerophosphocholine (5)
L-Methionine (5)
Hypoxanthine (5)
His-Glu (4)
Pro-Trp (4)
5-L-Glutamyl-L-alanine (4)
Val-Glu (4)
L-Norleucine (4)
Pyridoxal (Vitamin B6) (4)
N-Acetyl-D-glucosamine (4)

First Public Date

2026 (66)
2024 (42)
2022 (38)
2025 (34)
2023 (29)
2020 (22)
2014 (22)
2021 (19)
2019 (16)
2017 (16)
2018 (12)
2013 (12)
2015 (10)
2016 (5)

Study status

Terminated (1)

Study type

Transcription profiling by array (145)
RNA-seq of coding RNA (34)
Comparative genomic hybridization by array (11)
RNA-seq of coding RNA from single cells (10)
Unknown experiment type (9)
Methylation profiling by array (6)
RNA-seq of non coding RNA (4)
Other (3)
Cell line - High-throughput sequencing (2)
ATAC-seq (2)
MicroRNA profiling by array (2)
Methylation profiling by high throughput sequencing (2)
RNA-seq of total RNA (2)
Cell line - Methylation microarray (1)
ChIP-chip by tiling array (1)
Human - High-throughput sequencing (1)
Animal - High-throughput sequencing (1)
ChIP-chip by array (1)
Genotyping by array (1)
Capture-C (1)
Bisulfite-seq (1)
DNA-seq (1)
Proteomic profiling by array (1)
Interventional (1)

Release Date

2022 (581)
2025 (532)
2023 (492)
2021 (485)
2024 (434)
2020 (424)
2019 (281)
2017 (270)
2018 (250)
2016 (248)
2014 (244)
2015 (235)
2013 (158)
2012 (132)
2011 (101)
2010 (93)
2026 (81)
2009 (61)
2008 (53)
2007 (37)
2006 (17)
2005 (12)
2004 (5)
2003 (4)
2002 (4)
2000 (2)
1999 (1)

Lab affiliation

Ottawa Institute of Systems Biology and Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, 451 Smyth Road, Ottawa, Ontario K1H 8M5, Canada (3)
Department of Ophthalmology, LMU University Hospital, LMU Munich, Munich, Germany (2)
Institute of Molecular Medicine and Cell Research, University Freiburg (2)
University of Houston, Houston, TX 77204 (2)
1. Gavin Herbert Eye Institute - Center for Translational Vision Research, Department of Ophthalmology, University of California Irvine, CA, 92697, USA 2. Department of Physiology and Biophysics, School of Medicine, University of California Irvine, CA (1)
1Center for Advanced Vision Science, University of Virginia School of Medicine, Charlottesville, Virginia, USA (1)
1Department of Ophthalmology, Stem Cell Ocular Regenerative Medicine Center, Wilmer Eye Institute, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA. (1)
Aarhus University (1)
Adele Niessen Professor of Ophthalmology Vice Chair for Research FM Kirby Center for Molecular Ophthalmology Scheie Eye Institute University of Pennsylvania (1)
Barbara M. Braunger, Institute of Neuroanatomy, University Clinic Hamburg-Eppendorf, Hamburg, Germany (1)
Bascom Palmer Eye Institute University of Miami (1)
Dame Kate Campbell Fellow Department of Surgery| Melbourne Medical School Department of Anatomy and Physiology| School of Biomedical Sciences Faculty of Medicine, Dentistry and Health Sciences Medical Building (#181), Grattan Street The University of Melbourne, Victoria 3010 Australia P: +61 3 9035 5464 E: apebay@unimelb.edu.au W: https://medicine.unimelb.edu.au/school-structure/surgery W: https://biomedicalsciences.unimelb.edu.au/departments/anatomy-and-physiology (1)
Department of Biology, University of Fribourg Chemin du Musée 10, 1700 Fribourg, Switzerland T +41 26 300 8631 (1)
Department of Human Molecular Genetics and Biochemistry, Sackler Faculty of Medicine and Sagol School of Neurosciences, Tel Aviv University, Tel Aviv 69978, Israel (1)
Department of Infectious Diseases, Immunology and Sexual Health and Department of Medicine, St George Hospital, University of New South Wales, 2 South Street, Kogarah, Sydney, NSW 2217, Australia (1)
Department of Medicine, section of Physiology and Biochemistry, University of Perugia (1)
Department of Ophthalmology, University of California, Irvine, CA 92697 (1)
Department of Ophthalmology, Hadassah Medical Center, Jerusalem, Israel (1)
Department of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences, University at Buffalo (1)
Dept of pathology, Vision research foundation, Chennai, India (1)
Duke University, Albert Eye Research Institute (1)
Eye & Vison Health, Flinders University School of Medicine Flinders Medical Center Flinders University Australia (1)
Faculty of Medicine, St George and Sutherland Clinical School, University of New South Wales, St George Hospital, Sydney, New South Wales, Australia (1)
Functional Proteomics Laboratory, Centro Nacional de Biotecnología, CSIC, Calle Darwin 3, Campus de Cantoblanco, 28049 Madrid, Spain. (1)
Harald Junge, Ph.D. Mary and Marian Robinson Chair in Macular Degeneration Associate Professor and Research Director Department of Ophthalmology and Visual Neuroscience University of Minnesota Room 310A LRB, 2001 6th St SE Minneapolis, MN 55455 office: (612) 624-6017 web: https://med.umn.edu/ophthalmology/research/junge-lab (1)
Hopital Ophtalmique Jules-Gonin Group « Macular Degeneration and Diabetic Retinopathy » Av. de France 15 1002 Lausanne Switzerland (1)
Institute for Ophthalmic Research Eberhard-Karls University of Tuebingen Elfriede-Aulhorn-Str. 7 D-72076 Tuebingen. Germany. (1)
Lab for Retinal Cell Biology, Department of Ophthalmology, University of Zürich, Wagistrasse 14, Schlieren, CH 8952, Switzerland (1)
Max Planck Institute for Multidisciplinary Sciences, Bioanalytical Mass Spectrometry Group, Göttingen, Germany University Medical Center Göttingen, Department of Clinical Chemistry, Bioanalytics Group, Göttingen, Germany (1)
Novartis Institutes for Biomedical Research, 22 Windsor Street, Cambridge MA 02139, USA (1)

Location

France (1)

Keyword

Informal caregivers (1)
Cost effectiveness (1)
Cohort study (1)
Randomized study (1)
Elderly (1)

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Human Plasma Metabolomics in Age-related Macular Degeneration (AMD) Using Nuclear Magnetic Resonance Spectroscopy

Not available

ORGANISM(S): Homo sapiens

ST000590 | MetabolomicsWorkbench

Expression data for human retinal pigment epithelium (RPE)/choroid - early age-related macular degeneration (AMD) and control samples

Purpose: Age-related degeneration (AMD) is a major cause of blindness in developed countries. The molecular pathogenesis of early events in AMD is poorly understood. We investigated differential gene expression in samples of human retinal pigment epithelium (RPE)/choroid from early AMD and control m...

ORGANISM(S): Homo sapiens

2013-12-23 | E-GEOD-50195 | biostudies-arrayexpress

Transcriptomic and proteomic retinal pigment epithelium signatures of age-related macular degeneration

To identify disease-specific transcriptional programs in retinal pigment epithelium (RPE) cells, fibroblasts from 43 patients with geographic atrophy (GA) were reprogrammed into induced pluripotent stem cells (iPSCs) before being differentiated into RPE and compared to those from 36 healthy individu...

ORGANISM(S): Homo sapiens

2022-06-20 | E-MTAB-11642 | biostudies-arrayexpress

Illumina Infinium HumanMethylationEPIC DNA methylation microarray of human donor whole-blood from patients with and without Age-related Macular Degeneration

DNA methylation microarray analysis was performed on human donor whole blood samples from patients with and without AMD. A total of 30 patient samples including 16 Normal, 3 AREDS grade 2 (early AMD) and 11 AREDS grade 3 (intermediate AMD) (AMD total, n = 14) were selected. Samples were obtained fro...

ORGANISM(S): Homo sapiens

2021-12-31 | E-MTAB-11279 | biostudies-arrayexpress

Retinal pigment epithelium extracellular vesicles are potent inducers of age-related macular degeneration disease phenotype in the outer retina

Age-related macular degeneration (AMD) is a leading cause of blindness. Vision loss is caused by the loss of the retinal pigment epithelium (RPE) and photoreceptors and/or retinal and choroidal angiogenesis. Here we use AMD patient specific RPE cells with the Y402H high-risk polymorphism in the comp...

ORGANISM(S): Homo Sapiens (ncbitaxon:9606)

2022-01-21 | MSV000088713 | MassIVE

Whole genome methylation profiling of the retinal pigment epithelium of individuals with age-related macular degeneration

Illumina Infinium HumanMethylation450 BeadChip data from genomic DNA of retinal pigment epithelium from Age-related Macular Degeneration patients or age-matched controls.

ORGANISM(S): Homo sapiens

2019-08-01 | E-MTAB-7183 | biostudies-arrayexpress

Nitration of Tyrosines In Complement Factor H Domains Alters Its Immunological Activity and Mediates A Pathogenic Role In Age Related Macular Degeneration

Nitrosative stress has been implicated in the pathogenesis of age related macular degeneration (AMD). Tyrosine nitration is a unique type of post translational modification that occurs in the setting of inflammation and nitrosative stress. To date, the significance and functional implications of tyr...

ORGANISM(S): Homo sapiens (Human)

2017-08-29 | PXD005613 | Pride

Molecular biomarkers of neovascular age-related macular degeneration with incomplete response to anti-vascular endothelial growth factor treatment

The standard treatment for neovascular age-related macular degeneration (nAMD) consists of intravitreal anti-vascular endothelial growth factors (VEGF). However, for some patients, even maximal anti-VEGF treatment does notentirely suppress exudative activity. The goal of this study was to identify m...

ORGANISM(S): Homo sapiens (Human)

2021-01-18 | PXD022471 | Pride

Epigenetic Regulation of IL17RC in Age-related Macular Degeneration

This SuperSeries is composed of the following subset Series: GSE28002: Gene expression of the whole mouse eye GSE28032: Epigenetic Regulation of IL17RC in Age-related Macular Degeneration (MeDIP-chip) Refer to individual Series

ORGANISM(S): Mus musculus

2011-03-22 | E-GEOD-28033 | biostudies-arrayexpress

Association of sildenafil use with age-related macular degeneration: a retrospective cohort study.

Not available

S-EPMC10946355 | biostudies-literature

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