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ProteomicsDissecting post-translational modifications in Leptospira proteome to elucidate novel insights into pathogen-host interaction using bioinformatics approach
Leptospirosis is a zoonotic disease caused by Leptospira spp. that cause serious health burden. Humans are accidental host gets infected from water contaminated with Leptospira from urine of reservoir hosts like rodents and other mammals. Currently there is no effective vaccine available for leptosp...
ORGANISM(S): Leptospira interrogans serovar Copenhageni str. Fiocruz L1-130 
2022-08-12 | PXD030370 | Pride
Leptospira  protein modification  drug target  diagnosis  mass spectrometry  proteome discoverer 
ProteomicsDifferentially expressed extracellular proteins of Leptospira under the physiological conditions of infection
Leptospirosis is a re-emerging zoonotic disease of global presence. If not diagnosed early, the disease progress to multi-organ failure and culminate in death. There is no effective vaccine or unambiguous early diagnostic methods to date. Extracellular proteins are expressed under pathogenic and inv...
ORGANISM(S): Leptospira Leptospira interrogans serovar Copenhageni str. Fiocruz L1-130 
2025-09-08 | PXD037702 | Pride
Leptospirosis Extracellular proteins Lc-ms/ms analysis Zoonotic disease 
ProteomicsChanges in OMPs of Leptospira under simulated physiological conditions of infection
Leptospirosis is a worldwide zoonotic disease caused bypathogenic Leptospiraspread through urine of infected animals. There are many gaps in understanding the pathophysiology of leptospirosis and the host immunity.This lack of knowledge hinders taking necessary steps in the development of a potentia...
ORGANISM(S): Leptospira interrogans serovar Icterohaemorrhagiae 
2025-09-08 | PXD035782 | Pride
Proteomics Pathogenic Leptospira 
ProteomicsProteomic analysis of extracellular proteins of Leptospira interrogans
Leptospira, the causative agent of leptospirosis is known to have several proteases with potential to degrade extracellular matrix. However, a multipronged approach to identify, classify, characterize and elucidate their role has not been attempted. In this study, we carried out in-depth proteomic a...
ORGANISM(S): Leptospira interrogans serovar Copenhageni str. Fiocruz L1-130 
2022-02-17 | PXD026044 | Pride
Proteomics Ls-ms/ms Leptospira interrogans 
ProteomicsProteomic approach and expression analysis revealed the differential expression of leptospiral proteases capable of ECM degradation
Leptospira, the causative agent of leptospirosis is known to have several proteases with potential to degrade extracellular matrix. However, a multipronged approach to identify, classify, characterize and elucidate their role has not been attempted. In this study, we carried out in-depth proteomic a...
ORGANISM(S): Leptospira interrogans serovar Copenhageni str. Fiocruz L1-130 
2018-04-18 | PXD009050 | Pride
High resolution proteomics Protease Pathogenesis Leptospira Metalloprotease 
ProteomicsOuter membrane proteome of Leptospira; revealing the bottom of iceberg
Leptospira, the causative agent of leptospirosis is known to have several proteases with potential to degrade extracellular matrix. However, a multipronged approach to identify, classify, characterize and elucidate their role has not been attempted. In this study, we carried out in-depth proteomic a...
ORGANISM(S): Leptospira interrogans serovar Copenhageni str. Fiocruz L1-130 
2020-09-01 | PXD016204 | Pride
Pathogenic high resolution proteomics Protease Pathogenesis Outer membrane Leptospira 
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