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UnknownHigh-affinity biomolecular interactions are modulated by low-affinity binders.
Not available
S-EPMC11316740 | biostudies-literature
UnknownPredicting and designing therapeutics against the Nipah virus.
Not available
S-EPMC6907750 | biostudies-literature
UnknownTargeting LLT1 as a potential immunotherapy option for cancer patients non-responsive to existing checkpoint therapies in multiple solid tumors.
Not available
S-EPMC11545609 | biostudies-literature
ProteomicsSINV-nsP3 mScarelt-tagged immunoprecipitation
1x107 cells HEK293 FLP-IN T-REX cells were infected with SINVnsP3-mScarlet (bait) or SINVwt (negative control) at 1 MOI. After 18 hours, cells were scrapped and spin down at 300 g 4°C for 10 mins. After the centrifugation, supernatants were discarded and cell pellet washed once with 1X PBS, followed...
ORGANISM(S): Homo sapiens (Human) 
2024-12-19 | PXD054117 | Pride
Sinv-nsp3 
ProteomicsMicrobiota regulation of proteolytic activity
Proteases constitute the largest enzyme gene family in vertebrates with intracellular and secreted proteases having critical roles in cellular and organ physiology. Intestinal tract contains diverse set of proteases mediating digestion, microbial responses, epithelial and immune signaling. Transit o...
ORGANISM(S): Homo sapiens (Human) 
2022-02-23 | PXD025127 | Pride
Gastrointestinal infections Β-glucuronidase Microbiota Proteolytic activity Metaproteomics 
ProteomicsLocalisation of the Golgi pH regulator GPR89 extends to the endoplasmic reticulum and confers selective dependency in breast cancer
Identification of targetable biology in breast cancer is an important unmet need, particularly for triple negative breast cancer (TNBC) where outcomes are poor and there are few licensed targeted therapies. Here, we identify the anion channel GPR89 as a novel breast cancer oncogene relevant in TNBC ...
ORGANISM(S): Homo sapiens (Human) 
2026-06-02 | PXD031422 | Pride
Gpr89 Triple negative breast cancer Er stress Ire1a 
UnknownNup358 binds to AGO proteins through its SUMO-interacting motifs and promotes the association of target mRNA with miRISC.
Not available
S-EPMC5286382 | biostudies-literature
ProteomicsAlphavirus infection triggers selective cytoplasmic translocation of nuclear RBPs with moonlighting antiviral roles
RNA is a central molecule for RNA viruses, acting as mRNA and genome. However, the interactions that viral (v)RNA establishes with the host cell is only starting to be elucidated. Here, we determine with unprecedented depth the composition of the ribonucleoproteins (RNPs) of the prototypical arthrop...
ORGANISM(S): Homo sapiens (Human) 
2024-12-19 | PXD029492 | Pride
Rna-binding proteins Vric 
UnknownA foundation model for generalizable disease detection from retinal images.
Not available
S-EPMC10550819 | biostudies-literature
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