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TranscriptomicsThe gamma secretase inhibitor LLNle induces apoptosis of human GBM tumor initiating cells
Glioblastomas (GBM) are poorly differentiated astrocytic tumors arising in the Central Nervous System (CNS), which despite aggressive treatments are still characterized by a fatal outcome. Several studies have shown the existence of a subpopulation of cells within glioma tumors displaying cancer ste...
ORGANISM(S): Homo sapiens 
2010-04-09 | E-GEOD-14581 | biostudies-arrayexpress
TranscriptomicsGenomic aberrations in distant fields from oral potentially malignant lesions by high resolution DNA flow cytometry and array-CGH
The aim of the study was to address the concept of field cancerization in oral cancer. The presence of genomic aberrations, indicative of chromosomal instability (CIN), in oral distant fields (ODFs) of visually normal and non-dysplastic mucosa at the mirror image from concomitant oral potentially ma...
ORGANISM(S): Homo sapiens 
2011-12-21 | E-GEOD-28906 | biostudies-arrayexpress
UnknownMapping the human connectome using diffusion MRI at 300 mT/m gradient strength: Methodological advances and scientific impact.
Not available
S-EPMC9121330 | biostudies-literature
TranscriptomicsChromosomal aberrations and aneuploidy in oral potentially malignant lesions: distinctive features for tongue.
The mucosae of the oral cavity are different at the histological level but are all exposed to common genotoxic agents. As a result of this exposure, changes in the mucosal epithelia develop giving rise to Oral Potentially Malignant Lesions (OPMLs), which with time may in turn progress to Oral Squamo...
ORGANISM(S): Homo sapiens 
2011-10-19 | E-GEOD-28868 | biostudies-arrayexpress
TranscriptomicsGenomic DNA damage in oral potentially malignant disorders (OPMDs) and oral squamous cell carcinomas (OSCCs). Early detection of DNA aneuploidy and chromosomal aberrations in non dysplastic OPMDs.
Oral potentially malignant disorders (OPMDs) may precede oral squamous cell carcinoma (OSCC). Early detection of OPMDs has a crucial role in OSCC prevention. DNA aneuploidy and chromosomal aberrations are markers of genomic DNA damage and chromosomal instability (CIN), which is involved in cancer d...
ORGANISM(S): Homo sapiens 
2015-10-23 | E-GEOD-66136 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human untreated B-cell chronic lymphocytic leukemia
B-cell chronic lymphocytic leukemia (B-CLL) shows an incredibly high heterogeneity in the clinical course, spanning from rapidly aggressive to completely indolent behaviour. In order to identify the correspondent gene expression variability, we investigated 29 cases of untreated B-CLL using microarr...
ORGANISM(S): Homo sapiens 
2008-06-12 | E-GEOD-4207 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of Acute Promyelocytic Leukemia samples from patients with wild type FLT3 or FLT3 mutations
In this series we described the gene expression profiles of 18 APL patients using a high density DNA-oligonucleotide microarray (Agilent) representing about 20.000 genes demonstrating the presence of a very uniform expression pattern of APL cases among which two mainly types of gene profiles were re...
ORGANISM(S): Homo sapiens 
2008-05-07 | E-GEOD-2550 | biostudies-arrayexpress
UnknownSilencing of aphid genes by dsRNA feeding from plants.
Not available
S-EPMC3187792 | biostudies-literature
UnknownEffect of human flavin-containing monooxygenase 3 polymorphism on the metabolism of aurora kinase inhibitors.
Not available
S-EPMC3588010 | biostudies-literature
UnknownDynamics of membrane potential variation and gene expression induced by Spodoptera littoralis, Myzus persicae, and Pseudomonas syringae in Arabidopsis.
Not available
S-EPMC3484130 | biostudies-literature
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