Transcription profiling of human untreated B-cell chronic lymphocytic leukemia

ABSTRACT: B-cell chronic lymphocytic leukemia (B-CLL) shows an incredibly high heterogeneity in the clinical course, spanning from rapidly aggressive to completely indolent behaviour. In order to identify the correspondent gene expression variability, we investigated 29 cases of untreated B-CLL using microarray. Firstly, two robust CLL clusters were identified applying multiple unsupervised clustering algorithms. Their separation was mainly determined by the differential expression of several genes included into two gene groups designated OxPhos and Lyn clusters. OxPhos gene cluster, previously identified in a subset of diffuse large B-cell lymphomas, comprises genes coding for some respiratory chain enzymes, ribosomal proteins and translation factors. Moreover, increased levels of genes involved i

ORGANISM(S): Homo sapiens

SUBMITTER: Rossana Maffei 

PROVIDER: E-GEOD-4207 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress