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TranscriptomicsTranscription profiling of human untreated B-cell chronic lymphocytic leukemia
B-cell chronic lymphocytic leukemia (B-CLL) shows an incredibly high heterogeneity in the clinical course, spanning from rapidly aggressive to completely indolent behaviour. In order to identify the correspondent gene expression variability, we investigated 29 cases of untreated B-CLL using microarr...
ORGANISM(S): Homo sapiens 
2008-06-12 | E-GEOD-4207 | biostudies-arrayexpress
TranscriptomicsInteraction between endothelium and chronic lymphocytic leukemia B-cells rescues from apoptosis and modulates gene expression profile of leukemic cells
Chronic lymphocytic leukemic B cells (CLL) reside in close contact with activated endothelial cells (EC) in infiltrated tissues. Here, we investigated the interactions between EC and CLL cells, highlighting molecular networks involved in this cellular crosstalk. We co-cultured purified CLL cells on ...
ORGANISM(S): Homo sapiens 
2011-12-31 | E-GEOD-28787 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of Acute Promyelocytic Leukemia samples from patients with wild type FLT3 or FLT3 mutations
In this series we described the gene expression profiles of 18 APL patients using a high density DNA-oligonucleotide microarray (Agilent) representing about 20.000 genes demonstrating the presence of a very uniform expression pattern of APL cases among which two mainly types of gene profiles were re...
ORGANISM(S): Homo sapiens 
2008-05-07 | E-GEOD-2550 | biostudies-arrayexpress
TranscriptomicsGene expression profiles of nurse-like cells (NLCs) generated in vitro from chronic lymphocytic leukemia in presence of lenalidomide
NLCs were generated in vitro by culturing PBMCs from CLL patients for 10 days with/without the addition of 0.5 µM lenalidomide. Then, nonadherent cells were removed by vigorous pipetting and the remaining adherent cells were harvested for analyses. We inspected the whole-genome gene expression prof...
ORGANISM(S): Homo sapiens 
2014-11-24 | E-GEOD-57861 | biostudies-arrayexpress
UnknownEndothelin-1 promotes survival and chemoresistance in chronic lymphocytic leukemia B cells through ETA receptor.
Not available
S-EPMC4046988 | biostudies-literature
UnknownEfficacy and safety of lixisenatide once daily versus exenatide twice daily in type 2 diabetes inadequately controlled on metformin: a 24-week, randomized, open-label, active-controlled study (GetGoal-X).
Not available
S-EPMC3781502 | biostudies-literature
TranscriptomicsDemethyl fructiculin A (SCO-1) induces apoptosis by inducing reactive oxygen species in mitochondria
Demethyl fructiculin A is a diterpenoid quinone component of the exudates from Salvia corrugata (SCO-1) leafes. SCO-1 was recently reported to induce anoikis in mammalian cell lines via a molecular mechanism involving the presence of the membrane scavenging receptor CD36. However, experiments perfor...
ORGANISM(S): Homo sapiens 
2010-10-15 | E-GEOD-19846 | biostudies-arrayexpress
UnknownHigh-fidelity approximation of grid- and shell-based sampling schemes from undersampled DSI using compressed sensing: Post mortem validation.
Not available
S-EPMC8631240 | biostudies-literature
UnknownEnhancing post-operative hypothyroidism treatment: rat thyroid autotransplantation into a pre-vascularized, retrievable cell pouch™ device.
Not available
S-EPMC12483921 | biostudies-literature
UnknownHippocampal capillary pericytes in post-stroke and vascular dementias and Alzheimer's disease and experimental chronic cerebral hypoperfusion.
Not available
S-EPMC10870440 | biostudies-literature
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