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TranscriptomicsTranscription profiling of human untreated B-cell chronic lymphocytic leukemia
B-cell chronic lymphocytic leukemia (B-CLL) shows an incredibly high heterogeneity in the clinical course, spanning from rapidly aggressive to completely indolent behaviour. In order to identify the correspondent gene expression variability, we investigated 29 cases of untreated B-CLL using microarr...
ORGANISM(S): Homo sapiens 
2008-06-12 | E-GEOD-4207 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of Acute Promyelocytic Leukemia samples from patients with wild type FLT3 or FLT3 mutations
In this series we described the gene expression profiles of 18 APL patients using a high density DNA-oligonucleotide microarray (Agilent) representing about 20.000 genes demonstrating the presence of a very uniform expression pattern of APL cases among which two mainly types of gene profiles were re...
ORGANISM(S): Homo sapiens 
2008-05-07 | E-GEOD-2550 | biostudies-arrayexpress
TranscriptomicsInteraction between endothelium and chronic lymphocytic leukemia B-cells rescues from apoptosis and modulates gene expression profile of leukemic cells
Chronic lymphocytic leukemic B cells (CLL) reside in close contact with activated endothelial cells (EC) in infiltrated tissues. Here, we investigated the interactions between EC and CLL cells, highlighting molecular networks involved in this cellular crosstalk. We co-cultured purified CLL cells on ...
ORGANISM(S): Homo sapiens 
2011-12-31 | E-GEOD-28787 | biostudies-arrayexpress
TranscriptomicsGene expression profiles of nurse-like cells (NLCs) generated in vitro from chronic lymphocytic leukemia in presence of lenalidomide
NLCs were generated in vitro by culturing PBMCs from CLL patients for 10 days with/without the addition of 0.5 µM lenalidomide. Then, nonadherent cells were removed by vigorous pipetting and the remaining adherent cells were harvested for analyses. We inspected the whole-genome gene expression prof...
ORGANISM(S): Homo sapiens 
2014-11-24 | E-GEOD-57861 | biostudies-arrayexpress
TranscriptomicsGene expression profiles of monocytes derived from chronic lymphocytic leukemia patients and normal controls
We collected monocytes from peripheral blood of 5 chronic lymphocytic leukemia (CLL) patients and 5 healthy donors and we performed gene expression analysis by microarray. Comparison of gene expression profiles (GEPs) between CLL-derived and normal monocytes was used to discover molecular abnormalit...
ORGANISM(S): Homo sapiens 
2013-01-10 | E-GEOD-35179 | biostudies-arrayexpress
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