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TranscriptomicsBlood gene expression profile of control and crystalline silica exposed rats
The present research aimed to investigate peripheral blood gene expression profiling as a minimally invasive surrogate approach to study silica-induced pulmonary toxicity. Rats were exposed to crystalline silica by inhalation (15 mg/m3, 6 hours/day, 5 days). Pulmonary damage and blood gene expressio...
ORGANISM(S): Rattus norvegicus 
2011-12-02 | E-GEOD-27023 | biostudies-arrayexpress
MetabolomicsImmunomodulatory fecal metabolites are associated with mortality in COVID-19 patients with respiratory failure
Respiratory failure and mortality from COVID-19 result from virus- and inflammation-induced lung tissue damage. The intestinal microbiome and associated metabolites are implicated in immune responses to respiratory viral infections, however their impact on progression of severe COVID-19 remains uncl...
2023-05-02 | MTBLS5288 | MetaboLights
TranscriptomicsPotentiation of neurotoxicity in double mutant mice with Pink1 ablation and A53T-SNCA overexpression
As the second most frequent neurodegenerative disorder of old age, ParkinsonM-bM-^@M-^Ys disease (PD) can result from autosomal dominant causes like increased alpha-synuclein (SNCA) dosage, or from autosomal recessive causes like PINK1 loss-of-function. Interactions between these triggers and their ...
ORGANISM(S): Mus musculus 
2014-11-04 | E-GEOD-60414 | biostudies-arrayexpress
TranscriptomicsLaternula elliptica siphon hypoxia treatment
The siphon taken from old and young Laternula elliptica, both control and subjected to hypoxic conditions, were compared.
ORGANISM(S): Laternula elliptica 
2014-02-20 | E-MEXP-3613 | biostudies-arrayexpress
TranscriptomicsLaternula elliptica gill hypoxia treatment
Two groups of Laternula elliptica, old and young, were subjected to both ambient control and hypoxic conditions, and their gills were extracted and hybridized on an array.
ORGANISM(S): Laternula elliptica 
2013-04-01 | E-MEXP-3611 | biostudies-arrayexpress
TranscriptomicsEffect of Mineralocorticoid Receptor deletion on glucocorticoid signalling in the macropahge
Inappropriate excess of the steroid hormone aldosterone, which is a mineralocorticoid receptor (MR) agonist, is associated with increased inflammation and risk of cardiovascular disease. MR antagonists are cardioprotective and antiinflammatory in vivo, and evidence suggests that they mediate these e...
ORGANISM(S): Mus musculus 
2010-07-30 | E-GEOD-23308 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of liver from p38aDhep, IkkbDhep, and control mice 4h after injection of diethylnitrosamine
Analysis of microarray data from livers 4 hr after DEN administration revealed changes in the expression of several genes relevant to regulation of reactive oxygen species (ROS) accumulation, cell death, and cell cycle control.
ORGANISM(S): Mus musculus 
2008-05-23 | E-TABM-351 | biostudies-arrayexpress
TranscriptomicsHepatic miRNA profiles and thyroid hormone homeostasis in rats exposed to dietary potassium perfluorooctanesulfonate (PFOS) [mRNA]
Perfluorooctanesulfonate (PFOS) has been widely used in a variety of industrial and commercial applications as a surfactant and stain repellent. PFOS causes liver damage (including liver tumors) in experimental animals, primarily via interaction with PPARa and CAR/PXR. We investigated the involvemen...
ORGANISM(S): Rattus norvegicus 
2015-08-01 | E-GEOD-69520 | biostudies-arrayexpress
MetabolomicsImpact of Diabetic Stress Conditions on Renal Cell Metabolome
Diabetic kidney disease is a major complication in diabetes mellitus, and the most common reason for end-stage renal disease. Patients suffering from diabetes mellitus encounter glomerular damage by basement membrane thickening, and develop albuminuria. Subsequently, albuminuria can deteriorate the ...
2019-10-08 | MTBLS1093 | MetaboLights
TranscriptomicsTranscript profiling of individual twin blastomeres derived by splitting 2-cell stage murine embryos
We have examined whether twin blastomeres from 2-cell stage mouse embryos differ in mRNA content. Amplified mRNA from 12 blastomeres derived from six embryos approximately mid-way through their second cell cycle was analyzed. Probes displaying normalized values greater than 0.25 were selected and ex...
ORGANISM(S): Mus musculus 
2010-05-28 | E-GEOD-21688 | biostudies-arrayexpress
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