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TranscriptomicsUltra-deep sequencing of plasma DNA identifies druggable mutations in hepatocellular carcinoma
The purpose of the study is to detect somatic mutations in hepatocellular carcinoma using circulating free-DNA. We used deep-sequencing data of a panel of 60 commonly mutated genes in hepatocellular carcinoma.
ORGANISM(S): Homo sapiens 
2018-04-29 | E-MTAB-5123 | biostudies-arrayexpress
TranscriptomicsGene-expression profiles of paired biopsies and explanted liver from hepatitis C virus (HCV)-infected individuals
OBJECTIVE: The number of patients with HCV-related cirrhosis is increasing, leading to a rising risk of complications and death. Prognostic stratification in patients with early-stage cirrhosis is still challenging. We aimed to develop and validate a clinically useful prognostic index based on genom...
ORGANISM(S): Homo sapiens 
2014-08-22 | E-GEOD-54101 | biostudies-arrayexpress
TranscriptomicsExpression profiles of 186-gene signature in Italian hepatitis C virus (HCV)-related liver cirrhosis
OBJECTIVE: The number of patients with HCV-related cirrhosis is increasing, leading to a rising risk of complications and death. Prognostic stratification in patients with early-stage cirrhosis is still challenging. We aimed to develop and validate a clinically useful prognostic index based on genom...
ORGANISM(S): Homo sapiens 
2014-08-22 | E-GEOD-54099 | biostudies-arrayexpress
TranscriptomicsExpression profiles of 186-gene signature in U.S. hepatitis C virus (HCV)-related liver cirrhosis
OBJECTIVE: The number of patients with HCV-related cirrhosis is increasing, leading to a rising risk of complications and death. Prognostic stratification in patients with early-stage cirrhosis is still challenging. We aimed to develop and validate a clinically useful prognostic index based on genom...
ORGANISM(S): Homo sapiens 
2014-08-22 | E-GEOD-54100 | biostudies-arrayexpress
TranscriptomicsIRF4, a master transcription factor, regulates genes involved in BCR signaling, antigen processing and presentation, and GC development [ChIP-chip]
Interferon regulatory factor 4 (IRF4) is a master transcription factor required for the maturation of germinal center B cells that eventually develop into antibody secreting plasma cells and memory B cells. IRF4-deficient mice exhibit a profound reduction in serum immunoglobulin levels. In spite of...
ORGANISM(S): Homo sapiens 
2015-12-15 | E-GEOD-64268 | biostudies-arrayexpress
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