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UnknownSecondary Bile Acid Derivatives Are Contributors to the Fecal Bile Acid Pool and Associated With Bile Acid-Modulating Nutrients.

Background

Accumulation of hydrophobic bile acids (BAs) is linked with cancer development. However, derivatives of deoxycholic acid (DCA) and lithocholic acid (LCA) produced via bacterial metabolism may mitigate the proinflammatory and cytotoxic effects of hydrophobic BAs. The impact of diet...
S-EPMC11934243 | biostudies-literature
GenomicsTranscriptional regulation of germinal center B and plasma cell fates by dynamical control of IRF4 (ChIP-seq)
Temporal analysis of Irf4 and PU.1 genome binding during B cell activation and differentiation in vitro using antigen (NP-Ficoll) CD40L and IL-2/4/5 cytokines (see Molecular Systems Biology 7:495 for details of cellular system). The results provide insight in the target genes and binding specificity...
ORGANISM(S): Mus musculus 
2013-05-04 | E-GEOD-46607 | biostudies-arrayexpress
UnknownGenome-centric evaluation of Burkholderia sp. strain SRS-W-2-2016 resistant to high concentrations of uranium and nickel isolated from the Savannah River Site (SRS), USA.
Savannah River Site (SRS), an approximately 800-km2 former nuclear weapons production facility located near Aiken, SC remains co-contaminated by heavy metals and radionuclides. To gain a better understanding on microbially-mediated bioremediation mechanisms, several bacterial strains resi...
S-EPMC5367793 | biostudies-literature
GenomicsHistone Reader BRWD1 Targets and Restricts Recombination to the Igk Locus
B lymphopoiesis requires that immunoglobulin genes be accessible to RAG1-RAG2 recombinase. However, the RAG proteins bind widely to open chromatin, which suggests that additional mechanisms must restrict RAG-mediated DNA cleavage. Here we show that developmental downregulation of interleukin 7 (IL-7...
ORGANISM(S): Mus musculus 
2015-08-24 | E-GEOD-63302 | biostudies-arrayexpress
GenomicsNitric oxide regulates gene expression in cancers by controlling histone posttranslational modifications [HiSeq 2000]
Dynamic changes in histone posttranslational modifications (PTMs) are important regulators of chromatin structure and gene transcription in both normal and disease settings. Herein, we describe a novel signaling mechanism of nitric oxide (•NO) by demonstrating its ability to modulate gene expressi...
ORGANISM(S): Homo sapiens 
2015-11-05 | E-GEOD-66318 | biostudies-arrayexpress
UnknownReduced apoptosis of monocytes and macrophages is associated with their persistence in wounds of diabetic mice.
Monocytes and macrophages (Mo/MΦ) rapidly accumulate in skin wounds after injury, then disappear as healing progresses. However, the mechanisms underlying their ultimate fate in wounds remain to be elucidated. Here, we show that apoptosis of Mo/MΦ parallels their reduction as wound healing progresse...
S-EPMC8043999 | biostudies-literature
UnknownEnhanced Proliferation of Ly6C+ Monocytes/Macrophages Contributes to Chronic Inflammation in Skin Wounds of Diabetic Mice.
Diabetic wounds are characterized by persistent accumulation of proinflammatory monocytes (Mo)/macrophages (MΦ) and impaired healing. However, the mechanisms underlying the persistent accumulation of Mo/MΦ remain poorly understood. In this study, we report that Ly6C+F4/80lo/- M...
S-EPMC7927918 | biostudies-literature
UnknownMonocyte/Macrophage Heterogeneity during Skin Wound Healing in Mice.
Monocytes (Mos)/macrophages (Mϕs) orchestrate biological processes critical for efficient skin wound healing. However, current understanding of skin wound Mo/Mϕ heterogeneity is limited by traditional experimental approaches such as flow cytometry and immunohistochemistry. Therefore, we sought to mo...
S-EPMC9643652 | biostudies-literature
UnknownModulation of IRAK4 as a therapeutic strategy against monosodium urate- and xanthine-induced inflammation in macrophages and HepG2 cells.

Background

Interleukin-1 receptor-associated kinase 4 (IRAK4) is a pivotal mediator of Toll-like receptor (TLR) and interleukin-1 receptor (IL-1R) signaling, critically involved in innate immune activation and pro-inflammatory cytokine production. Dysregulated IRAK4 activity contributes to c...
S-EPMC12823803 | biostudies-literature
UnknownImproved predictions of transcription factor binding sites using physicochemical features of DNA.
Typical approaches for predicting transcription factor binding sites (TFBSs) involve use of a position-specific weight matrix (PWM) to statistically characterize the sequences of the known sites. Recently, an alternative physicochemical approach, called SiteSleuth, was proposed. In this approach, a ...
S-EPMC3526315 | biostudies-literature
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