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UnknownSubphenotypes in acute respiratory distress syndrome: latent class analysis of data from two randomised controlled trials.

Background

Subphenotypes have been identified within heterogeneous diseases such as asthma and breast cancer, with important therapeutic implications. We assessed whether subphenotypes exist within acute respiratory distress syndrome (ARDS), another heterogeneous disorder.

Methods

We ...
S-EPMC4154544 | biostudies-literature
UnknownUse of risk reclassification with multiple biomarkers improves mortality prediction in acute lung injury.

Objective

Multiple single biomarkers have been associated with poor outcomes in acute lung injury; however, no single biomarker has sufficient discriminating power to clearly indicate prognosis. Using both derivation and replication cohorts, we tested novel risk reclassification methods to d...
S-EPMC3260884 | biostudies-literature
UnknownNIST Interlaboratory Study on Glycosylation Analysis of Monoclonal Antibodies: Comparison of Results from Diverse Analytical Methods.
Glycosylation is a topic of intense current interest in the development of biopharmaceuticals because it is related to drug safety and efficacy. This work describes results of an interlaboratory study on the glycosylation of the Primary Sample (PS) of NISTmAb, a monoclonal antibody reference materia...
S-EPMC6944243 | biostudies-literature
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