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TranscriptomicsThe HDAC inhibitor panobinostat (LBH589) inhibits Acute Lymphoblastic leukemia (ALL) in vitro and in vivo in a new characterized human ALL mice model (Illumina)
Histone deacetylases (HDACs) have been identified as therapeutic targets due to regulatory function in DNA structure and organization. We have analyzed the role of the LBH589, a novel pan inhibitor of class I and II HDACs, in Acute Lymphoblastic Leukemia. In vitro, LBH589 was shown to induce a dose...
ORGANISM(S): Homo sapiens 
2012-04-17 | E-GEOD-26791 | biostudies-arrayexpress
TranscriptomicsThe HDAC inhibitor panobinostat (LBH589) inhibits Acute Lymphoblastic leukemia (ALL) in vitro and in vivo in a new characterized human ALL mice model (SNP)
Histone deacetylases (HDACs) have been identified as therapeutic targets due to regulatory function in DNA structure and organization. We have analyzed the role of the LBH589, a novel pan inhibitor of class I and II HDACs, in Acute Lymphoblastic Leukemia. In vitro, LBH589 was shown to induce a dose...
ORGANISM(S): Homo sapiens 
2012-04-17 | E-GEOD-26792 | biostudies-arrayexpress
UnknownFurther evidence for the impact of a genome-wide-supported psychosis risk variant in ZNF804A on the Theory of Mind Network.
Not available
S-EPMC3957114 | biostudies-literature
TranscriptomicsH. salinarum NRC-1 vs VNG2099C knockout
To investigate the contribution of ribonucleases to post-transcriptional regulation of mRNA levels, we examined the fitness consequences and gene expression changes of ribonuclease mutants in the extreme halophilic archaeon Halobacterium salinarum NRC-1. H. salinarum NRC-1 is known to use a large re...
ORGANISM(S): Halobacterium sp. NRC-1 
2014-03-03 | E-GEOD-45988 | biostudies-arrayexpress
TranscriptomicsHuman uterine Natural Killer cells regulate differentiation of extravillous trophoblast early in pregnancy - scRNA-seq data
We used trophoblast organoids differentiating to extravillous trophoblast (EVT) to study the effects of key cytokines secreted by uterine Natural Killer (uNK) cells on EVT behaviour. Specifically, we exposed the organoids to four uNK-derived cytokines (CSF1, CSF2, XCL1, CCL5) and collected cells at ...
ORGANISM(S): Homo sapiens 
2024-01-10 | E-MTAB-13382 | biostudies-arrayexpress
TranscriptomicsPlacental infection single-cell and single-nuclei maps
This resource comprises a single-cell multi-lineage map of first trimester infected placental cells. We have included data from both uninfected cells and cells infected with three pathogens known to cause maternal and fetal disorders: Plasmodium falciparum, Listeria monocytogenes, and Toxoplasma gon...
ORGANISM(S): Homo sapiens 
2024-03-01 | E-MTAB-12795 | biostudies-arrayexpress
TranscriptomicsscRNA-seq and snucRNA-seq of human primary trophoblast organoids (PTO) and trophoblast stem cells (TSCs) differentiation into extravillous trophoblast organoids (EVTs)
This study aims to compare in vivo human trophoblast differentiation into EVTs to different in vitro trophoblast organoids using single-cell and single-nuclei RNA sequencing. The study includes two type of systems: human primary trophoblast organoids (PTO) and trophoblast stem cells (TSCs). Tropho...
ORGANISM(S): Homo sapiens 
2023-02-09 | E-MTAB-12650 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of Arabidopsis to assess spiking
Transcript profiling is crucial to study biological systems and various platforms have been implemented to survey mRNAs at the genome scale. We have assessed the characteristics of the CATMA microarray designed for Arabidopsis thaliana transcriptome analysis, and compared it with two commercial plat...
ORGANISM(S): Arabidopsis thaliana 
2004-11-23 | E-MEXP-197 | biostudies-arrayexpress
UnknownDifferentiation of Prior SARS-CoV-2 Infection and Postacute Sequelae by Standard Clinical Laboratory Measurements in the RECOVER Cohort.
Not available
S-EPMC11408082 | biostudies-literature
UnknownSex Differences in Long COVID.
Not available
S-EPMC11755195 | biostudies-literature
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