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ProteomicsMultisite phosphorylation by protein kinase A mediates modality-specific modulation of PIEZO2
Protein kinase A is a downstream effector of many inflammatory mediators that induce pain hypersensitivity by increasing the mechanosensitivity of nociceptive sensory afferent. Here we examine the molecular mechanism underlying protein kinase-Adependent modulation of the mechanically-activated ion c...
ORGANISM(S): Mus musculus (Mouse) 
2023-07-20 | PXD041372 | Pride
Lc-ms/ms Piezo2 Protein kinase a Proteomics Phosphorylation 
ProteomicsTargeting the AKT/mTOR pathway attenuates the metastatic potential of colorectal carcinoma circulating tumor cells in a murine xenotransplantation model
Circulating tumor cells (CTCs) play an important role in metastasis formation. Aberrant signaling of oncogenic pathways (e.g. PI3K/AKT/mTOR pathway) drives tumor progression. In this work, the susceptibility of the colon cancer CTC derived cell line, CTC-MCC-41, for AKT and mTOR inhibitors was evalu...
ORGANISM(S): Homo sapiens (Human) 
2025-04-14 | PXD054001 | Pride
Ctcs  pi3k/akt/mtor pathway  akt isoforms  xenotransplantation model  proteomics  mk2206  rad001  colorectal carcinoma  drug sensitivity assays  dual targeting  personalized medicine  targeted therapy 
ProteomicsMultiomic profiling of medulloblastoma reveals subtype-specific targetable alterations at the proteome and N-glycan level - Technical and Biological Validation
Medulloblastomas (MBs) are malignant pediatric brain tumors that are molecularly and clinically very heterogenous. To unravel phenotypically relevant MB subtypes, we compiled a harmonized proteome dataset of 167 MBs and integrated findings with DNA methylation and N-glycome data. Six proteome MB sub...
ORGANISM(S): Homo sapiens (Human) 
2024-06-03 | PXD048767 | Pride
Proteomics Validation Medulloblastoma 
TranscriptomicsSplicing factor 1 modulates dietary restriction and TORC1 pathway longevity in C. elegans
RNA-seq of C.elegans strain N2 (wt) with and without sfa-1 RNAi at adult day 3 and day 15, C. elegans strain DA1116 (eat-2(ad1116)) with and without sfa-1 RNAi at adult day 3, day 15, and day 27, C. elegans strain SS104 (glp-4(bn2)) with and without hrp-2 RNAi at adult day 1, and HeLa cells with and...
ORGANISM(S): Caenorhabditis elegans 
2016-11-29 | E-MTAB-4866 | biostudies-arrayexpress
UnknownThe impact of viral mutations on recognition by SARS-CoV-2 specific T cells.
Not available
S-EPMC8552693 | biostudies-literature
UnknownsodC-based real-time PCR for detection of Neisseria meningitidis.
Not available
S-EPMC3088665 | biostudies-literature
UnknownWhole brain radiation therapy alone versus radiosurgery for patients with 1-10 brain metastases from small cell lung cancer (ENCEPHALON Trial): study protocol for a randomized controlled trial.
Not available
S-EPMC6048892 | biostudies-literature
UnknownCOVID-19 due to the B.1.617.2 (Delta) variant compared to B.1.1.7 (Alpha) variant of SARS-CoV-2: a prospective observational cohort study.
Not available
S-EPMC9240087 | biostudies-literature
UnknownTrabectedin for recurrent WHO grade 2 or 3 meningioma: A randomized phase II study of the EORTC Brain Tumor Group (EORTC-1320-BTG).
Not available
S-EPMC9071312 | biostudies-literature
UnknownClinical features and management of human monkeypox: a retrospective observational study in the UK.
Not available
S-EPMC9300470 | biostudies-literature
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