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ProteomicsTranscriptomic and Proteomic Response of HC-04 to hepatocyte growth factor (HGF)
The routine study of human malaria liver-stage biology in vitro is hampered by low infection efficiency of human hepatocellular carcinoma (HCC) lines (<0.1%), poor understanding of steady-state HCC biology, and lack of appropriate tools for trace sample analysis. HC-04 is the only HCC that supports ...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2016-07-20 | MSV000079959 | MassIVE
ProteomicsProteome of the rodent malaria parasite Plasmodium berghei liver stage merosomes
We use the Plasmodium berghei rodent model to characterize the proteome of the final phase of liver stage development, the merosomes, packets of hepatic merozoites that bud from the host hepatocyte to initiate the blood stage of malaria. Plasmodium berghei WT ANKA strain was used to infect HepG2 hep...
ORGANISM(S): Bos taurus (Bovine) Homo sapiens (Human) Plasmodium berghei ANKA Anopheles stephensi (Asian malaria mosquito) 
2019-03-25 | PXD010559 | Pride
Plasmodium Proteomics Malaria Merosomes 
TranscriptomicsTranscription profiling of human peripheral blood monocytes from volunteers in a malaria vaccine trial
Volunteers were assessed at study entry, the day of the third vaccination and 24, 72 hours, two weeks after vaccination, and 5 days after challenge. 13/39 vaccinees were protected and 26/39 were not protected. Eleven vaccinees exhibited delayed onset of parasitemia. All infectivity controls develope...
ORGANISM(S): Homo sapiens 
2009-10-10 | E-GEOD-18323 | biostudies-arrayexpress
TranscriptomicsIdentification of a subtelomeric gene family expressed during the asexual-sexual stage transition in Plasmodium falciparum
For malaria transmission, the parasite must undergo sexual differentiation into mature gametocytes. However, the molecular basis for this critical transition in the parasites life cycle is unknown. Six previously uncharacterized genes, Pfg14.744, Pfg14.745, Pfg14.748, Pfg14.763, Pfg14.752 and Pfg6.6...
ORGANISM(S): Plasmodium falciparum 
2014-10-16 | E-GEOD-62364 | biostudies-arrayexpress
TranscriptomicsHost cell transcripts during malaria liver stage infection reveals a coordinated and sequential set of biological events
After entering their mammalian host via the bite of an Anopheles mosquito, Plasmodium sporozoites migrate to the liver where they traverse several hepatocytes before invading the one inside which they will develop and multiply into thousands of merozoites. Although this constitutes an essential step...
ORGANISM(S): Mus musculus 
2010-05-14 | E-GEOD-14967 | biostudies-arrayexpress
TranscriptomicsBulk RNA-seq of the human malaria parasite Plasmodium falciparum 3D7 cultured under different iron conditions
Background: Host iron deficiency is protective against severe malaria as the human malaria parasite Plasmodium falciparum depends on free iron from its host to proliferate. Due to the absence of transferrin, ferritin, ferroportin, and a functional heme oxygenase, the parasite’s essential pathways of...
ORGANISM(S): Plasmodium falciparum 
2024-04-08 | E-MTAB-13411 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse hepatocytes reinfected with Plasmodium berghei
We show that an ongoing malaria blood stage infection impairs the establishment of Plasmodium sporozoites in hepatocytes and that secondary infections can only be established after a previous infection has been cleared from circulation. Using control mice, mice infected with sporozoites only, mice i...
ORGANISM(S): Mus musculus 
2010-11-01 | E-TABM-839 | biostudies-arrayexpress
UnknownPlasmodium vivax liver stage assay platforms using Indian clinical isolates.
Not available
S-EPMC7310233 | biostudies-literature
TranscriptomicsRNA-seq of Plasmodium vivax derived from clinical isolates
This project contains RNA-sequencing reads of Plasmodium vivax derived directly from clinical patients. Here, we aim to characterize the gene expression patterns in patients with various parasite compositions. Patients (n=10) were recruited from two malaria endemic areas in Thailand. Ten RNA samples...
ORGANISM(S): Homo sapiens 
2019-06-30 | E-MTAB-6753 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse cerebral malaria susceptible and resistant animals
Cerebral malaria (CM) is a leading cause of death in the world. Better understanding of the pathogenesis of this disease is critical for the development of novel therapies. In this work, we investigated temporal gene expression profiles in the brains of CM-susceptible and CM-resistant mice during in...
ORGANISM(S): Mus musculus 
2008-06-15 | E-GEOD-7814 | biostudies-arrayexpress
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