Transcription profiling of mouse hepatocytes reinfected with Plasmodium berghei

ABSTRACT: We show that an ongoing malaria blood stage infection impairs the establishment of Plasmodium sporozoites in hepatocytes and that secondary infections can only be established after a previous infection has been cleared from circulation. Using control mice, mice infected with sporozoites only, mice infected by iRBCs only or mice reinfected, we show that this impairment is not due to an effect of the acquired host immune response or to a decrease in host cell survival. Instead, an ongoing blood stage infection leads to a significant increase in the expression of hepcidin, a peptide hormone that is secreted by the liver and controls body iron homeostasis. A rapid increase of hepcidin levels during blood stage infection causes sequestration of iron in storage forms within cells of reticuloendo

ORGANISM(S): Mus musculus

DISEASE(S): P. berghei NK65 infected erythrocyte's infection

SUBMITTER: Celine Carret 

PROVIDER: E-TABM-839 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress