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TranscriptomicsP. falciparum Heterochromatin Protein 1 Marks Genomic Loci Linked to Phenotypic Variation of Exported Virulence Factors
Epigenetic processes are the main conductors of phenotypic variation in eukaryotes. The malaria parasite Plasmodium falciparum employs antigenic variation of the major surface antigen PfEMP1, encoded by 60 var genes, to evade acquired immune responses. PfEMP1 also mediates sequestration of infected ...
ORGANISM(S): Plasmodium falciparum 
2010-05-06 | E-GEOD-17029 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human peripheral blood monocytes from volunteers in a malaria vaccine trial
Volunteers were assessed at study entry, the day of the third vaccination and 24, 72 hours, two weeks after vaccination, and 5 days after challenge. 13/39 vaccinees were protected and 26/39 were not protected. Eleven vaccinees exhibited delayed onset of parasitemia. All infectivity controls develope...
ORGANISM(S): Homo sapiens 
2009-10-10 | E-GEOD-18323 | biostudies-arrayexpress
ProteomicsAn Exported Kinase Family Mediates Species-Specific Erythrocyte Remodelling and Virulence in Human Malaria
The most severe form of human malaria is caused by Plasmodium falciparum. Its virulence is closely linked to the increase in rigidity and cytoadhesion of infected erythrocytes, which obstruct blood flow to vital organs. Unlike other human-infecting Plasmodium species, P. falciparum exports a family ...
ORGANISM(S): Homo sapiens (Human) Plasmodium falciparum (isolate 3D7) Plasmodium knowlesi strain H 
2020-04-17 | PXD015833 | Pride
Plasmodium Fikk kinases Malaria Red blood cell Phosphorylation 
ProteomicsEnvironmental inhibition of RNA Pol III reduces malaria parasite virulence (during asymptomatic infection)
During the dry season, in many African regions, persistent asymptomatic malaria cases have been linked to downregulated virulence gene expression encoded by the var gene family, resulting in low adhesion and increased circulation time of Plasmodium falciparum-infected erythrocytes 1. Several studies...
ORGANISM(S): Plasmodium falciparum 
2024-06-25 | PXD040576 | Pride
Var genes Malaria virulence Ruf6 ncrna Plasmodium falciparum Antigenic variation 
GenomicsNutrient sensing modulates malaria parasite virulence.
Nutrient sensing modulates malaria parasite virulence.
PRJNA286025 | ENA
ProteomicsExploring the virulence gene interactome with CRISPR/dCas9 in the human malaria parasite
The var multigene family encodes clonally variant surface antigens that are key to immune evasion and pathogenesis in the human malaria parasite, Plasmodium falciparum. Epigenetics and nuclear organization regulate the var gene family in a system of mutually exclusive expression; however, few factor...
ORGANISM(S): Plasmodium falciparum (isolate 3D7) 
2020-07-15 | PXD013131 | Pride
Malaria Dcas9 Crispr Interactome 
ProteomicsHistone lactylation: a new epigenetic mark in the malaria parasite Plasmodium
In the malaria parasite Plasmodium falciparum, epigenetic modifications such as acetylation and methylation play important roles in parasite biology and virulence. Here, we characterised a new epigenetic mark, histone lactylation, recently discovered in humans and also present in Plasmodium. It was ...
ORGANISM(S): Plasmodium knowlesi strain H Plasmodium falciparum NF54 
2025-12-15 | PXD055236 | Pride
Lactylation Histone Mass spec Malaria Epigenetics 
GenomicsA comprehensive epigenome map of Plasmodium falciparum reveals unique mechanisms of transcriptional regulation
Epigenetic mechanisms have been poorly understood in Plasmodium falciparum, the causative agent of malaria. To elucidate stage specific epigenetic regulations in P. falciparum, we performed genome-wide mapping of various histone modifications, nucleosomes and RNA Polymerase II. Our comprehensive ana...
ORGANISM(S): Plasmodium falciparum 
2015-09-23 | E-GEOD-63369 | biostudies-arrayexpress
UnknownThe machinery underlying malaria parasite virulence is conserved between rodent and human malaria parasites.
Not available
S-EPMC4894950 | biostudies-literature
TranscriptomicsRNA-seq of mosquito transmitted and blood transmitted Plasmodium chabaudi
This study is a collaboration with Phil Spence and Jean Langhorne at NIMR, Mill Hill where Phil is studying the differences in aetiology of rodent malaria when mice are infected by mosquito bite versus intraperitoneal injection of blood stage parasites. The aim is to determining transcriptomic diffe...
ORGANISM(S): Plasmodium chabaudi chabaudi 
2012-11-27 | E-ERAD-95 | biostudies-arrayexpress
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