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ProteomicsCysteine oxidation as a regulatory mechanism of Arabidopsis plastidial NAD-dependent malate dehydrogenase
Malate dehydrogenases (MDHs) catalyze a reversible NAD(P)-dependent-oxidoreductase reaction that plays an important role in central metabolism and redox homeostasis of plant cells. Recent studies suggest a moonlighting function of plastidial NAD-dependent MDH (plNAD-MDH) in plastid biogenesis, indep...
ORGANISM(S): Escherichia Coli 
2024-04-29 | PXD048384 | JPOST Repository
MetabolomicsMultiple acyl-coA dehydrogenase deficiency kills Mycobacterium tuberculosis in vitro and during infection

The human pathogen Mycobacterium tuberculosis (Mtb) devotes a significant fraction of its genome to fatty acid metabolism. Although Mtb depends on host fatty acids as a carbon source, fatty acid b-oxidation is mediated by genetically redundant enzymes, which has hampered the development of antitu...

2021-09-29 | MTBLS2374 | MetaboLights
MetabolomicsMitochondrial KMT9 methylates DLAT to control pyruvate dehydrogenase activity and prostate cancer growth

Prostate cancer (PCa) growth depends on de novo lipogenesis controlled by the mitochondrial pyruvate dehydrogenase complex (PDC). In this study, we identified lysine methyltransferase (KMT)9 as a novel regulator of PDC activity. KMT9 is localized in mitochondria of PCa cells, but not in mitochond...

2024-12-10 | MTBLS2452 | MetaboLights
MetabolomicsABHD11/ROLIP maintains the TCA cycle by preserving functional lipoylation of the 2-oxoglutarate dehydrogenase complex
2-oxoglutarate (2-OG) relates mitochondrial metabolism to cell function: conversion of 2-OG to succinyl-CoA by the 2-OG dehydrogenase complex (OGDHc) is rate-limiting for the Tricarboxylic Acid (TCA) cycle, but 2-OG is also required for oxygen sensitive enzymes (2-OG dependent dioxygenases) that hav...
2020-08-10 | MTBLS1875 | MetaboLights
MetabolomicsUse of Aspartate Dehydrogenase by cancer cells
Not available
ORGANISM(S): Homo sapiens 
ST000154 | MetabolomicsWorkbench
ProteomicsTime-resolved analysis of proteolytic cleavage sites in Malate dehydrogenase by Trypsin.
A proteolytic cleavage experiment was performed with the protein Malate dehydrogenase (MDH) and Trypsin protease, to identify early cleavage sites in MDH. Various concentrations of Trypsin (5,000, 10,000 and 100,000 x diluted) were tested and early timepoints taken to detect only few cleavage sites...
ORGANISM(S): Sus scrofa domesticus (domestic pig) 
2024-09-20 | PXD047437 | Pride
Trypsin Mass spectrometry Malate dehydrogenase 
ProteomicsHypothalamic malate dehydrogenase 2 (MDH2) modulates systemic glucose metabolism through oxytocin-mediated thermogenesis
Bariatric surgery improves hyperglycemia in obesity and type 2 diabetes (T2D), yet its central mechanisms remain unclear. Through cerebrospinal fluid proteomic profiling of rats, we identify reduced central malate dehydrogenase 2 (MDH2) levels that correlate with surgery-induced restoration of normo...
ORGANISM(S): Rattus Norvegicus 
2025-12-19 | PXD072275 |
ProteomicsIdentification of non-specific phosphatases in TCA cycle regulation
Protein phosphorylation is a well-established post-translational mechanism that regulates protein functions and metabolic pathways. It has been shown that several plant mitochondrial proteins are phosphorylated in a reversible manner. However, the identity of the phosphatases/kinases involved in thi...
ORGANISM(S): Arabidopsis Thaliana (mouse-ear Cress) 
2021-04-01 | PXD018412 | JPOST Repository
MetabolomicsPlasmodium falciparum stable-isotope carbon labeling to explore metabolic consequences of keto–acid dehydrogenase disruption
Not available
ORGANISM(S): Plasmodium falciparum 
ST002024 | MetabolomicsWorkbench
GenomicsMetabolic regulation of the glioblastoma stem cell epitranscriptome by malate dehydrogenase 2 (MDH2)
Metabolic regulation of the glioblastoma stem cell epitranscriptome by malate dehydrogenase 2 (MDH2)
PRJNA1075313 | ENA
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