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Male subfertility or infertility is a common condition often characterized by men producing a low number of sperm with poor quality. To gain insight into this condition, we performed a quantitative proteomic analysis of semen samples obtained from infertile and fertile men.
ORGANISM(S): Homo sapiens (Human) 
2024-08-09 | PXD046594 | Pride
Antibody microarray based profiling of twelve urine samples.
3 healthy female
3 heatlhy male
3 female with pancreatic cancer
3 male with pancreatic cancer
ORGANISM(S): Homo sapiens 
Reversible and sub-lethal stresses to the mitochondria elicit a program of compensatory responses that ultimately improve mitochondrial function, a conserved anti-aging mechanism termed mitohormesis. Here, we show that harmol, a member of the beta-carbolines family with anti-depressant properties, i...
2023-05-26 | MTBLS7533 | MetaboLights
Background & Aims: Overnutrition is one of the major causes of non-alcoholic fatty liver disease (NAFLD) and its advanced form non-alcoholic steatohepatitis (NASH). Besides the quantity of consumed calories, distinct dietary components are increasingly recognized as important contributor to the path...
ORGANISM(S): Mus musculus 
The goal of this study was to determine the effects of a well-characterized anti-androgen, abiraterone acetate, and a suspected human anti-androgen, di-n-butyl phthalate (DBP) on the androgenic function of human fetal testis. Human fetal testis was xenografted into the renal subcapsular space of cas...
ORGANISM(S): Homo sapiens 
Animal models play a critical role in the study of Huntington’s disease (HD), for example to elucidate underlying molecular mechanisms or to develop novel therapeutic venues. One of the first transgenic mouse models of HD, the R6/2 line, has been described in 1996 and has since become one of the mos...
ORGANISM(S): Mus musculus (Mouse) 
2019-06-03 | PXD013771 | Pride
41 volunteers (male non-smokers) were exposed to formaldehyde (FA) vapors for 4 h per day over a period of 5 working days under strictly controlled conditions. For each exposure day, different exposure concentrations were used in a random order ranging from 0 up to 0.7 ppm. At concentrations of 0.3 ...
ORGANISM(S): Homo sapiens 
Transcriptional profiling of S. mansoni pairing-experienced males (EM) vs. pairing unexperienced males (UM) Two conditions (EM vs. UM) with three biological samples of EM and in parallel other three biological samples of UM. For each sample (three EM and three UM) were performed four technical rep...
ORGANISM(S): Schistosoma mansoni 
Since the human prostate does not undergo replicative senescence but rather undergoes transdifferentiation with increasing age, we investigated the molecular profile of prostate fibroblasts induced to transdifferentiate in response to TGF-b1.
ORGANISM(S): Homo sapiens 
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